Incidence of second sarcomas: a cancer registry-based study.

Details

Serval ID
serval:BIB_220962317833
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Incidence of second sarcomas: a cancer registry-based study.
Journal
Cancer Causes and Control : Ccc
Author(s)
Levi F., Randimbison L., Maspoli-Conconi M., Blanc-Moya R., La Vecchia C.
ISSN
1573-7225 (Electronic)
ISSN-L
0957-5243
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
25
Number
4
Pages
473-477
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
BACKGROUND: In high-quality cancer registration systems, about one in eight incident cancers are second primary cancers. This is due to a combination of careful diagnostic ascertainment, shared genetic determinants, shared exposure to environmental factors and consequences of treatment for first cancer.
METHODS: We used data derived from the Swiss population-based cancer Registries of Vaud and Neuchâtel, including 885,000 inhabitants.
RESULTS: Among 107,238 (52% males) first cancers occurring between 1976 and 2010, a total of 126 second sarcomas were observed through active and passive follow-up versus 68.2 expected, corresponding to a standardized incidence ratio (SIR) of 1.85 (95 % CI 1.5-2.2). Significant excess sarcoma risks were observed after skin melanoma (SIR = 3.0), breast cancer (2.2), corpus uteri (2.7), testicular (7.5), thyroid cancer (4.2), Hodgkin lymphoma (5.7) and leukemias (4.0). For breast cancer, the SIR was 3.4 ≥5 years after sarcoma diagnosis.
CONCLUSIONS: The common denominator of these neoplasms is the utilization of radiotherapy in their management. Some sarcomas following breast cancer may be due to shared genetic components (i.e., in the Li-Fraumeni syndrome), as well as possibly to shared environmental factors, with sarcomas, including overweight, selected dietary and reproductive factors which are, however, too little defined for any quantitative risk assessment.
Pubmed
Web of science
Create date
11/04/2014 18:36
Last modification date
20/08/2019 13:58
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