Response heterogeneity as a new biomarker of treatment response in patients with neuroendocrine tumors.

Details

Serval ID
serval:BIB_21FF4C20D634
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Response heterogeneity as a new biomarker of treatment response in patients with neuroendocrine tumors.
Journal
Future oncology
Author(s)
Dromain C., Pavel M., Ronot M., Schaefer N., Mandair D., Gueguen D., Cheng C., Dehaene O., Schutte K., Cahané D., Jégou S., Balazard F.
ISSN
1744-8301 (Electronic)
ISSN-L
1479-6694
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Aim: The RAISE project aimed to find a surrogate end point to predict treatment response early in patients with enteropancreatic neuroendocrine tumors (NET). Response heterogeneity, defined as the coexistence of responding and non-responding lesions, has been proposed as a predictive marker for progression-free survival (PFS) in patients with NETs. Patients & methods: Computerized tomography scans were analyzed from patients with multiple lesions in CLARINET (NCT00353496; n = 148/204). Cox regression analyses evaluated association between response heterogeneity, estimated using the standard deviation of the longest diameter ratio of target lesions, and NET progression. Results: Greater response heterogeneity at a given visit was associated with earlier progression thereafter: week 12 hazard ratio (HR; 95% confidence interval): 1.48 (1.20-1.82); p < 0.001; n = 148; week 36: 1.72 (1.32-2.24); p < 0.001; n = 108. HRs controlled for sum of longest diameter ratio: week 12: 1.28 (1.04-1.59); p = 0.020 and week 36: 1.81 (1.20-2.72); p = 0.005. Conclusion: Response heterogeneity independently predicts PFS in patients with enteropancreatic NETs. Further validation is required.
Keywords
RECIST, biomarker, neuroendocrine tumors, progression-free survival, response heterogeneity
Pubmed
Web of science
Create date
28/07/2023 16:58
Last modification date
08/08/2023 6:57
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