Immunoisolated xenogenic chromaffin cell therapy for chronic pain. Initial clinical experience
Details
Serval ID
serval:BIB_21E6B3F69378
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunoisolated xenogenic chromaffin cell therapy for chronic pain. Initial clinical experience
Journal
Anesthesiology
ISSN
0003-3022 (Print)
Publication state
Published
Issued date
11/1996
Volume
85
Number
5
Pages
1005-12; discussion 29A-30A
Notes
Journal Article --- Old month value: Nov
Abstract
BACKGROUND: Chromaffin cells from the adrenal gland secrete a mixture of compounds that have a strong analgesic effect, especially when administered intrathecally. Many studies in animal models have shown that discordant xenogeneic cell isolates, including chromaffin cells, can survive and have biologic effects when transplanted within a semipermeable membrane capsule. METHODS: To evaluate the clinical potential of encapsulated cell therapy, a human-scale implant containing bovine chromaffin cells was developed, characterized, and implanted in the subarachnoid space of seven patients with severe chronic pain not satisfactorily managed with conventional therapies. Patients received no pharmacologic immunosuppression. Cell devices were implanted during minimally invasive surgery, and device design allowed retrieval. All devices were recovered after implant periods of 41 to 176 days. RESULTS: Postexplant histologic analysis, immunostaining, and secretory function all confirmed survival and biochemical function of the encapsulated cells. Reductions in morphine intake and improvement in pain ratings were observed in several patients. CONCLUSIONS: This study represents the first successful trial of encapsulated xenogeneic cells in humans. The preliminary findings of pain reduction warrant the initiation of a randomized, double-blind phase II study to evaluate the potential efficacy of the procedure.
Keywords
Adult
Aged
Animals
Cattle
Chromaffin Cells/*transplantation
Chronic Disease
Drug Delivery Systems/instrumentation
*Drug Implants
Female
Humans
Male
Membranes, Artificial
Middle Aged
Palliative Care/*methods
Transplantation, Heterologous
Pubmed
Web of science
Create date
28/01/2008 11:41
Last modification date
20/08/2019 13:58