Age-dependent gain of alternative splice forms and biased duplication explain the relation between splicing and duplication.

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Serval ID
serval:BIB_21E4AE52DF8C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Age-dependent gain of alternative splice forms and biased duplication explain the relation between splicing and duplication.
Journal
Genome Research
Author(s)
Roux J., Robinson-Rechavi M.
ISSN
1549-5469 (Electronic)
ISSN-L
1088-9051
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
21
Number
3
Pages
357-363
Language
english
Abstract
We analyze here the relation between alternative splicing and gene duplication in light of recent genomic data, with a focus on the human genome. We show that the previously reported negative correlation between level of alternative splicing and family size no longer holds true. We clarify this pattern and show that it is sufficiently explained by two factors. First, genes progressively gain new splice variants with time. The gain is consistent with a selectively relaxed regime, until purifying selection slows it down as aging genes accumulate a large number of variants. Second, we show that duplication does not lead to a loss of splice forms, but rather that genes with low levels of alternative splicing tend to duplicate more frequently. This leads us to reconsider the role of alternative splicing in duplicate retention.
Pubmed
Web of science
Open Access
Yes
Create date
14/12/2010 11:32
Last modification date
20/08/2019 13:58
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