Monocyte deactivation in septic shock.

Details

Serval ID
serval:BIB_21AF53398F3E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Monocyte deactivation in septic shock.
Journal
Current Opinion in Infectious Diseases
Author(s)
Heumann D., Glauser M.P., Calandra T.
ISSN
0951-7375
Publication state
Published
Issued date
06/1998
Peer-reviewed
Oui
Volume
11
Number
3
Pages
279-283
Language
english
Notes
Publication types: Journal Article
Abstract
Septic shock is a complicated syndrome in which pro-inflammatory and anti-inflammatory processes are dynamically interconnected and regulated. Central to these processes is the monocyte, which produces large quantities of pro-inflammatory cytokines in the presence of bacterial products. During the course of sepsis, the production of compensatory anti-inflammatory mechanisms may deactivate monocytes and lead to a state of paralysis. This situation is in fact similar but not identical to that known as tolerance, in which normal monocytes prechallenged with lipopolysaccharide do not respond to a second challenge of lipopolysaccharide. Here, we review some of the cellular mechanisms that may lead to monocyte deactivation and discuss the clinical implications they may have.
Pubmed
Web of science
Create date
25/01/2008 13:28
Last modification date
20/08/2019 12:58
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