Oxidative and nonoxidative glucose metabolism following graded doses of oral glucose in man.

Details

Serval ID
serval:BIB_218AF2ED1EE8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Oxidative and nonoxidative glucose metabolism following graded doses of oral glucose in man.
Journal
Diabète and Métabolisme
Author(s)
Moeri R., Golay A., Schutz Y., Temler E., Jequier E., Felber J.P.
ISSN
0338-1684 (Print)
ISSN-L
0338-1684
Publication state
Published
Issued date
1988
Peer-reviewed
Oui
Volume
14
Number
1
Pages
1-7
Language
english
Abstract
The oxidative and nonoxidative glucose metabolism represent the two major mechanisms of the utilization of a glucose load. Eight normal subjects were administered oral loads of 50, 100 and 150 g glucose and gas exchange measurements were performed for eight hours by means of computerized continuous indirect calorimetry. The glycemic peaks were almost identical with all three doses with a rise to between 141 and 147 mg/dl at 60 min. The fall back to basal level was reached later with the high than with the low glucose doses. The glucose oxidation rate rose to values between 223 and 253 mg/min after the three glucose doses, but while falling immediately after the peak at 120 min following the 50 g load, the glucose oxidation rate remained at its maximum rate until 210 min for the 100 g glucose load and plateaued up to 270 min for the 150 g glucose dose. The oxidation rates then fell gradually to reach basal levels at 270, 330 and 420 min according to the increasing size of the load. Altogether 55 +/- 3 g glucose were oxidized during the 8 hours following the 50 g glucose load, 75 +/- 3 g after the 100 g load and 80 +/- 5 g after the 150 g load. The nonoxidative glucose disposal, which corresponds essentially to glucose storage, varied according to the size of the glucose load, with uptakes of 20 +/- 1, 60 +/- 1 and 110 +/- 1 g glucose 180 min after the 50, 100 and 150 g glucose loads respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Administration, Oral, Adult, Blood Glucose/metabolism, Fatty Acids, Nonesterified/blood, Glucose/administration & dosage, Glucose/metabolism, Humans, Insulin/blood, Male, Oxidation-Reduction, Reference Values
Pubmed
Web of science
Create date
21/01/2008 13:08
Last modification date
20/08/2019 12:58
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