Oxidative and nonoxidative glucose metabolism following graded doses of oral glucose in man.
Details
Serval ID
serval:BIB_218AF2ED1EE8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Oxidative and nonoxidative glucose metabolism following graded doses of oral glucose in man.
Journal
Diabète and Métabolisme
ISSN
0338-1684 (Print)
ISSN-L
0338-1684
Publication state
Published
Issued date
1988
Peer-reviewed
Oui
Volume
14
Number
1
Pages
1-7
Language
english
Abstract
The oxidative and nonoxidative glucose metabolism represent the two major mechanisms of the utilization of a glucose load. Eight normal subjects were administered oral loads of 50, 100 and 150 g glucose and gas exchange measurements were performed for eight hours by means of computerized continuous indirect calorimetry. The glycemic peaks were almost identical with all three doses with a rise to between 141 and 147 mg/dl at 60 min. The fall back to basal level was reached later with the high than with the low glucose doses. The glucose oxidation rate rose to values between 223 and 253 mg/min after the three glucose doses, but while falling immediately after the peak at 120 min following the 50 g load, the glucose oxidation rate remained at its maximum rate until 210 min for the 100 g glucose load and plateaued up to 270 min for the 150 g glucose dose. The oxidation rates then fell gradually to reach basal levels at 270, 330 and 420 min according to the increasing size of the load. Altogether 55 +/- 3 g glucose were oxidized during the 8 hours following the 50 g glucose load, 75 +/- 3 g after the 100 g load and 80 +/- 5 g after the 150 g load. The nonoxidative glucose disposal, which corresponds essentially to glucose storage, varied according to the size of the glucose load, with uptakes of 20 +/- 1, 60 +/- 1 and 110 +/- 1 g glucose 180 min after the 50, 100 and 150 g glucose loads respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Administration, Oral, Adult, Blood Glucose/metabolism, Fatty Acids, Nonesterified/blood, Glucose/administration & dosage, Glucose/metabolism, Humans, Insulin/blood, Male, Oxidation-Reduction, Reference Values
Pubmed
Web of science
Create date
21/01/2008 14:08
Last modification date
20/08/2019 13:58