BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells.

Details

Serval ID
serval:BIB_21652EDF357B
Type
Article: article from journal or magazin.
Collection
Publications
Title
BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells.
Journal
Ultrastructural Pathology
Author(s)
Finzi G., Franzi F., Placidi C., Acquati F., Palumbo E., Russo A., Taramelli R., Sessa F., La Rosa S.
ISSN
1521-0758 (Electronic)
ISSN-L
0191-3123
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
32
Number
6
Pages
246-251
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
BACE2 is a protease homologous to BACE1 protein, an enzyme involved in the amyloid formation of Alzheimer disease (AD). However, despite the high homology between these two proteins, the biological role of BACE2 is still controversial, even though a few studies have suggested a pathogenetic role in sporadic inclusion-body myositis and hereditary inclusion-body myopathy, which are characterized by vacuolization of muscular fibers with intracellular deposits of proteins similar to those found in the brain of AD patients. Although BACE2 has also been identified in the pancreas, its function remains unknown and its specific localization in different pancreatic cell types has not been definitively ascertained. For these reasons, the authors have investigated the cellular and subcellular localization of BACE2 in normal rodent pancreases. BACE2 immunoreactivity was found in secretory granules of beta cells, co-stored with insulin and IAPP, while it was lacking in the other endocrine and exocrine cell types. The presence of BACE2 in secretory granules of beta cells suggests that it may play a role in diabetes-associated amyloidogenesis.
Keywords
Amyloid Precursor Protein Secretases/metabolism, Amyloid Precursor Protein Secretases/ultrastructure, Animals, Aspartic Acid Endopeptidases/metabolism, Aspartic Acid Endopeptidases/ultrastructure, Immunohistochemistry, Insulin-Secreting Cells/enzymology, Insulin-Secreting Cells/ultrastructure, Mice, Microscopy, Electron, Transmission, Rats, Secretory Vesicles/enzymology, Secretory Vesicles/ultrastructure
Pubmed
Web of science
Create date
06/09/2016 14:14
Last modification date
20/08/2019 12:58
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