Venom Systems as Models for Studying the Origin and Regulation of Evolutionary Novelties.

Details

Serval ID
serval:BIB_216418A5928B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Venom Systems as Models for Studying the Origin and Regulation of Evolutionary Novelties.
Journal
Molecular biology and evolution
Author(s)
Zancolli G., Casewell N.R.
ISSN
1537-1719 (Electronic)
ISSN-L
0737-4038
Publication state
Published
Issued date
27/05/2020
Peer-reviewed
Oui
Volume
37
Number
10
Pages
2777-2790
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
A central goal in biology is to determine the ways in which evolution repeats itself. One of the most remarkable examples in nature of convergent evolutionary novelty is animal venom. Across diverse animal phyla, various specialized organs and anatomical structures have evolved from disparate developmental tissues to perform the same function, that is, produce and deliver a cocktail of potent molecules to subdue prey or predators. Venomous organisms therefore offer unique opportunities to investigate the evolutionary processes of convergence of key adaptive traits, and the molecular mechanisms underlying the emergence of novel genes, cells, and tissues. Indeed, some venomous species have already proven to be highly amenable as models for developmental studies, and recent work with venom gland organoids provides manipulatable systems for directly testing important evolutionary questions. Here, we provide a synthesis of the current knowledge that could serve as a starting point for the establishment of venom systems as new models for evolutionary and molecular biology. In particular, we highlight the potential of various venomous species for the study of cell differentiation and cell identity, and the regulatory dynamics of rapidly evolving, highly expressed, tissue-specific, gene paralogs. We hope that this review will encourage researchers to look beyond traditional study organisms and consider venom systems as useful tools to explore evolutionary novelties.
Keywords
adaptive traits, convergent evolution, evodevo, regulatory elements, toxins, transcription factors
Pubmed
Web of science
Open Access
Yes
Create date
10/06/2020 22:14
Last modification date
30/03/2021 6:34
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