Evaluation of postmortem measurement of NT-proBNP as a marker for cardiac function.

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Serval ID
serval:BIB_2159C11100A3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evaluation of postmortem measurement of NT-proBNP as a marker for cardiac function.
Journal
International Journal of Legal Medicine
Author(s)
Michaud K, Augsburger M, Donzé N, Sabatasso S, Faouzi M, Bollmann M, Mangin P
ISSN
0937-9827,1437-1596
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
122
Number
5
Pages
415-420
Language
english
Abstract
Clinical biomarkers of cardiac function could also be monitored postmortem. Among the natriuretic peptides, the aminoterminal portion of pro-brain natriuretic peptide (NT-proBNP) appears to be a more reliable postmortem tool than the BNP, owing to its longer half-life and greater stability. In living persons, NT-proBNP is considered to be a marker of heart failure, and its level rises after cardiac ischemia. The goal of this study was first to evaluate the postmortem stability of NT-proBNP, then to measure the NT-proBNP levels in postmortem cases of heart failure related to coronary ischemia. The goal of this study was also to evaluate the correlations between different specimens collected at autopsy (e.g. blood, serum, vitreous humor and pericardial fluid). The study included 96 cases, which were classified into 4 groups according to the autopsy and histological findings. The NT-proBNP levels were significantly higher in individuals who had suffered from chronic cardiac ischemia, with or without acute coronary events, than in either control cases or those who had suffered from acute thromboembolism or acute rupture of a plaque without chronic cardiac ischemia. The highest levels were registered in individuals who had suffered from acute coronary thromboembolism in association with chronic coronary ischemia. Good correlations in the NT-proBNP levels for the different specimens were observed between samples of femoral blood, serum, and pericardial fluid. Our data indicated that postmortem measurements of NT-proBNP are reliable and compatible with clinical findings.
Keywords
Adult, Age Factors, Aged, Aged, 80 and over, Biological Markers/metabolism, Case-Control Studies, Coronary Artery Disease/metabolism, Coronary Artery Disease/pathology, Coronary Thrombosis/metabolism, Coronary Thrombosis/pathology, Embolism, Female, Forensic Pathology, Humans, Logistic Models, Male, Middle Aged, Myocardial Ischemia/metabolism,
Pubmed
Web of science
Open Access
Yes
Create date
25/06/2008 13:45
Last modification date
01/10/2019 6:17
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