Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells

Details

Serval ID
serval:BIB_2149A569BDBD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells
Journal
Nature
Author(s)
Held  W., Roland  J., Raulet  D. H.
ISSN
0028-0836
Publication state
Published
Issued date
07/1995
Peer-reviewed
Oui
Volume
376
Number
6538
Pages
355-8
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jul 27
Abstract
An important feature of natural killer (NK) cell activity is the lysis of cells that have extinguished expression of some or all class I major histocompatibility (MHC) molecules. Accordingly, the Ly49A NK-cell antigen receptor has been shown to deliver an inhibitory signal to NK cells on encounter with Dd or Dk class I MHC on target cells. Ly49A belongs to a family of eight or more highly related, tightly linked genes. Expression of Ly49A and Ly49C, another member of the Ly49 family with distinct MHC specificity, define subpopulations of NK cells that are only partly overlapping. The mechanisms regulating the expression of LY49 family members are unknown. We show here that the Ly49A and Ly49C NK-cell receptors are each subject to allelic exclusion. Because Ly49 genes are not thought to undergo DNA rearrangement, allelic exclusion of Ly49 genes could involve a mechanism distinct from that used by B and T lymphocytes and is likely to play an important role in the genesis of a putative NK-cell repertoire specific for class I molecules.
Keywords
Alleles Animals *Antigens, Ly Base Sequence Cells, Cultured Cloning, Molecular DNA Primers Histocompatibility Antigens Class I/*genetics/immunology Killer Cells, Natural/*immunology Lectins, C-Type Membrane Glycoproteins/*genetics/immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Molecular Sequence Data Receptors, Immunologic/*genetics/immunology
Pubmed
Web of science
Create date
17/01/2008 15:24
Last modification date
20/08/2019 12:57
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