Zeitpunkt der Medikamenten-einnahme bei Hypertonie und Angina pectoris. Eine kontrollierte Uberwachungsstudie. [Time of drug intake in hypertension and angina pectoris. A controlled monitoring study]

Details

Serval ID
serval:BIB_212A0D292DF3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Zeitpunkt der Medikamenten-einnahme bei Hypertonie und Angina pectoris. Eine kontrollierte Uberwachungsstudie. [Time of drug intake in hypertension and angina pectoris. A controlled monitoring study]
Journal
Schweizerische Rundschau fur Medizin Praxis
Author(s)
Erne P., Saxenhofer H., Waeber B., Heynen G.
ISSN
1013-2058
Publication state
Published
Issued date
1994
Volume
83
Number
39
Pages
1079-83
Language
german
Notes
Clinical Trial
Controlled Clinical Trial
English Abstract
Journal Article
Abstract
A prospective cross-over study was performed in a general practice environment to assess and compare compliance data obtained by electronic monitoring on a BID or QD regimen in 113 patients with hypertension or angina pectoris. All patients were on a BID regimen (nifedipine SR) during the first month and switched to QD regimen (amlodipine) for another month. Taking compliance (i.e. the proportion of days with correct dosing) improved in 30% of patients (95% confidence interval 19 to 41%, p < 0.001), when switching from a BID to a QD regimen, but at the same time there was a 15% increase (95% confidence interval 5 to 25%, p < 0.02) in the number of patients with one or more no-dosing days. About 8% of patients had a low compliance rate, irrespective of the dosage regimen. Actual dosage intervals were used to estimate extent and timing of periods with unsatisfactory drug activity for various hypothetical drug durations of action, and it appears that the apparent advantage of QD regimen in terms of compliance is clinically meaningful only, when the duration of activity extents beyond the dosage interval in all patients.
Keywords
AgedAmlodipine/administration & dosage/therapeutic useAngina Pectoris/*drug therapyConfidence IntervalsCross-Over StudiesFemaleHumansHypertension/*drug therapyMaleMiddle AgedNifedipine/administration & dosage/therapeutic usePatient ComplianceProspective Studies
Pubmed
Create date
04/03/2009 15:04
Last modification date
20/08/2019 12:57
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