Clara cells drive eosinophil accumulation in allergic asthma.

Details

Serval ID
serval:BIB_211A4F6DC95C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clara cells drive eosinophil accumulation in allergic asthma.
Journal
European Respiratory Journal
Author(s)
Sonar S.S., Ehmke M., Marsh L.M., Dietze J., Dudda J.C., Conrad M.L., Renz H., Nockher W.A.
ISSN
1399-3003 (Electronic)
ISSN-L
0903-1936
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
39
Number
2
Pages
429-438
Language
english
Notes
Publication types: Journal Article
Abstract
Development of allergic asthma is a complex process involving immune, neuronal and tissue cells. In the lung, Clara cells represent a major part of the "immunomodulatory barrier" of the airway epithelium. To understand the contribution of these cells to the inflammatory outcome of asthma, disease development was assessed using an adjuvant-free ovalbumin model. Mice were sensitised with subcutaneous injections of 10 μg endotoxin-free ovalbumin in conjunction with naphthalene-induced Clara cell depletion. Clara epithelial cell depletion in the lung strongly reduced eosinophil influx, which correlated with decreased eotaxin levels and, moreover, diminished the T-helper cell type 2 inflammatory response, including interleukin (IL)-4, IL-5 and IL-13. In contrast, airway hyperresponsiveness was increased. Further investigation revealed Clara cells as the principal source of eotaxin in the lung. These findings are the first to show that Clara airway epithelial cells substantially contribute to the infiltration of eotaxin-responsive CCR3+ immune cells and augment the allergic immune response in the lung. The present study identifies Clara cells as a potential therapeutic target in inflammatory lung diseases such as allergic asthma.
Pubmed
Web of science
Open Access
Yes
Create date
01/04/2012 14:16
Last modification date
20/08/2019 12:57
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