Coexistence of inflammatory hepatocellular adenomas with HNF1α-inactivated adenomas: is there an association?

Details

Serval ID
serval:BIB_211777B6B50B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Coexistence of inflammatory hepatocellular adenomas with HNF1α-inactivated adenomas: is there an association?
Journal
Histopathology
Author(s)
Castain C., Sempoux C., Brunt E.M., Causse O., Heitzmann A., Hernandez-Prera J.C., Le Bail B., Schirmacher P., Thung S.N., Balabaud C., Bioulac-Sage P.
ISSN
1365-2559 (Electronic)
ISSN-L
0309-0167
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
64
Number
6
Pages
890-895
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
AIMS: To report the coexistence of inflammatory hepatocellular adenoma (IHCA) and HNF1α-inactivated HCA (H-HCA) in cases from a multicentre study.
METHODS AND RESULTS: We report nine cases with the coexistence of IHCA and H-HCA; eight occurred in women, and one in a man. The numbers of nodules and the sizes of the largest and smallest HCAs were variable. In one case, the nodules of the two different subtypes were discovered at different times. In all women, HCAs were histologically typical, regardless of their subtype, whereas H-HCA in the man differed histologically from classic H-HCA.
CONCLUSIONS: These cases suggest that a predisposition to develop multiple adenomas, hypothetically caused by a 'benign tumorigenic field effect', although common to all HCAs, may result in different genotypes and phenotypes. Although this is rare, it is expected that more cases with the coexistence of different genotypes will emerge, owing to progress in the use of specific immunohistochemical approaches.
Keywords
Adenoma, Liver Cell/metabolism, Adenoma, Liver Cell/pathology, Adult, Female, Hepatocyte Nuclear Factor 1-alpha/metabolism, Humans, Liver Neoplasms/metabolism, Liver Neoplasms/pathology, Male, Middle Aged, Tumor Markers, Biological
Pubmed
Web of science
Create date
05/01/2015 9:24
Last modification date
20/08/2019 12:57
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