Platelet glycoprotein IIb/IIIa blockade in acute ischemic stroke.

Details

Serval ID
serval:BIB_21105
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Platelet glycoprotein IIb/IIIa blockade in acute ischemic stroke.
Journal
Cerebrovascular Diseases (basel, Switzerland)
Author(s)
Bogousslavsky J., Leclerc J.R.
ISSN
1015-9770 (Print)
ISSN-L
1015-9770
Publication state
Published
Issued date
2001
Volume
11
Number
4
Pages
287-293
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
While thrombolytic therapy is approved in the United States and Canada for treatment of acute ischemic stroke, only a small number of patients are currently treated. Additional agents that could restore or improve cerebral flow are needed. Based on the experience in acute coronary syndromes, reperfusion agents such as platelet glycoprotein IIb/IIIa antagonists, alone or in combination with reduced doses of thrombolytic agents, have the potential for improving the safety and efficacy of recombinant tissue plasminogen activator (rt-PA). In addition, these newer agents may permit extension beyond the current 3-hour window from symptom onset used for systemic rt-PA.
Keywords
Acute Disease, Brain Ischemia/drug therapy, Humans, Platelet Aggregation Inhibitors/therapeutic use, Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors, Stroke/blood, Stroke/drug therapy, Thrombosis/prevention & control
Pubmed
Web of science
Create date
19/11/2007 12:16
Last modification date
20/08/2019 12:57
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