Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts.

Details

Serval ID
serval:BIB_210A40DE036E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts.
Journal
Molecular Psychiatry
Author(s)
Muglia P., Tozzi F., Galwey N.W., Francks C., Upmanyu R., Kong X.Q., Antoniades A., Domenici E., Perry J., Rothen S., Vandeleur C.L., Mooser V., Waeber G., Vollenweider P., Preisig M., Lucae S., Müller-Myhsok B., Holsboer F., Middleton L.T., Roses A.D.
ISSN
1476-5578[electronic], 1359-4184[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
15
Number
6
Pages
589-601
Language
english
Abstract
Major depressive disorder (MDD) is a highly prevalent disorder with substantial heritability. Heritability has been shown to be substantial and higher in the variant of MDD characterized by recurrent episodes of depression. Genetic studies have thus far failed to identify clear and consistent evidence of genetic risk factors for MDD. We conducted a genome-wide association study (GWAS) in two independent datasets. The first GWAS was performed on 1022 recurrent MDD patients and 1000 controls genotyped on the Illumina 550 platform. The second was conducted on 492 recurrent MDD patients and 1052 controls selected from a population-based collection, genotyped on the Affymetrix 5.0 platform. Neither GWAS identified any SNP that achieved GWAS significance. We obtained imputed genotypes at the Illumina loci for the individuals genotyped on the Affymetrix platform, and performed a meta-analysis of the two GWASs for this common set of approximately half a million SNPs. The meta-analysis did not yield genome-wide significant results either. The results from our study suggest that SNPs with substantial odds ratio are unlikely to exist for MDD, at least in our datasets and among the relatively common SNPs genotyped or tagged by the half-million-loci arrays. Meta-analysis of larger datasets is warranted to identify SNPs with smaller effects or with rarer allele frequencies that contribute to the risk of MDD.
Keywords
Colaus Study
Pubmed
Web of science
Open Access
Yes
Create date
02/03/2009 19:53
Last modification date
20/08/2019 13:57
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