A-Kinase Anchoring Protein-Lbc: A Molecular Scaffold Involved in Cardiac Protection.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_20D8CB9F630E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A-Kinase Anchoring Protein-Lbc: A Molecular Scaffold Involved in Cardiac Protection.
Journal
Journal of cardiovascular development and disease
Author(s)
Diviani D., Osman H., Reggi E.
ISSN
2308-3425 (Electronic)
ISSN-L
2308-3425
Publication state
Published
Issued date
08/02/2018
Peer-reviewed
Oui
Volume
5
Number
1
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Heart failure is a lethal disease that can develop after myocardial infarction, hypertension, or anticancer therapy. In the damaged heart, loss of function is mainly due to cardiomyocyte death and associated cardiac remodeling and fibrosis. In this context, A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that facilitate the spatiotemporal activation of the cyclic adenosine monophosphate (AMP)-dependent protein kinase (PKA) and other transduction enzymes involved in cardiac remodeling. AKAP-Lbc, a cardiac enriched anchoring protein, has been shown to act as a key coordinator of the activity of signaling pathways involved in cardiac protection and remodeling. This review will summarize and discuss recent advances highlighting the role of the AKAP-Lbc signalosome in orchestrating adaptive responses in the stressed heart.
Keywords
A-kinase anchoring protein (AKAP), cardiac protection, cardiomyocyte, cyclic AMP, protein kinase A, signal transduction
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Projects / 31003A_175838
Create date
16/01/2020 11:49
Last modification date
12/08/2020 6:08
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