Performance of Different Diagnostic Criteria for Familial Mediterranean Fever in Children with Periodic Fevers: Results from a Multicenter International Registry.

Details

Serval ID
serval:BIB_20D0F31BBD8C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Performance of Different Diagnostic Criteria for Familial Mediterranean Fever in Children with Periodic Fevers: Results from a Multicenter International Registry.
Journal
The Journal of rheumatology
Author(s)
Demirkaya E., Saglam C., Turker T., Koné-Paut I., Woo P., Doglio M., Amaryan G., Frenkel J., Uziel Y., Insalaco A., Cantarini L., Hofer M., Boiu S., Duzova A., Modesto C., Bryant A., Rigante D., Papadopoulou-Alataki E., Guillaume-Czitrom S., Kuemmerle-Deschner J., Neven B., Lachmann H., Martini A., Ruperto N., Gattorno M., Ozen S.
Working group(s)
Paediatric Rheumatology International Trials Organisations (PRINTO), Eurofever Project
ISSN
0315-162X (Print)
ISSN-L
0315-162X
Publication state
Published
Issued date
01/2016
Peer-reviewed
Oui
Volume
43
Number
1
Pages
154-160
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; Validation Studies
Publication Status: ppublish
Abstract
Our aims were to validate the pediatric diagnostic criteria in a large international registry and to compare them with the performance of previous criteria for the diagnosis of familial Mediterranean fever (FMF).
Pediatric patients with FMF from the Eurofever registry were used for the validation of the existing criteria. The other periodic fevers served as controls: mevalonate kinase deficiency (MKD), tumor necrosis factor receptor-associated periodic syndrome (TRAPS), cryopyrin-associated periodic syndrome (CAPS), aphthous stomatitis, pharyngitis, adenitis syndrome (PFAPA), and undefined periodic fever from the same registry. The performances of Tel Hashomer, Livneh, and the Yalcinkaya-Ozen criteria were assessed.
The FMF group included 339 patients. The control group consisted of 377 patients (53 TRAPS, 45 MKD, 32 CAPS, 160 PFAPA, 87 undefined periodic fevers). Patients with FMF were correctly diagnosed using the Yalcinkaya-Ozen criteria with a sensitivity rate of 87.4% and a specificity rate of 40.7%. On the other hand, Tel Hashomer and Livneh criteria displayed a sensitivity of 45.0 and 77.3%, respectively. Both of the latter criteria displayed a better specificity than the Yalcinkaya-Ozen criteria: 97.2 and 41.1% for the Tel Hashomer and Livneh criteria, respectively. The overall accuracy for the Yalcinkaya-Ozen criteria was 65 and 69.6% (using 2 and 3 criteria), respectively. Ethnicity and residence had no effect on the performance of the Yalcinkaya-Ozen criteria.
The Yalcinkaya-Ozen criteria yielded a better sensitivity than the other criteria in this international cohort of patients and thus can be used as a tool for FMF diagnosis in pediatric patients from either the European or eastern Mediterranean region. However, the specificity was lower than the previously suggested adult criteria.

Keywords
Chi-Square Distribution, Child, Child, Preschool, Cohort Studies, Diagnosis, Differential, Diagnostic Tests, Routine/methods, Europe, Familial Mediterranean Fever/classification, Familial Mediterranean Fever/diagnosis, Familial Mediterranean Fever/epidemiology, Female, Fever/classification, Fever/diagnosis, Fever/epidemiology, Hereditary Autoinflammatory Diseases/classification, Hereditary Autoinflammatory Diseases/diagnosis, Hereditary Autoinflammatory Diseases/epidemiology, Humans, Internationality, Male, Registries, Retrospective Studies, Severity of Illness Index, Statistics, Nonparametric
Pubmed
Create date
05/12/2016 19:22
Last modification date
21/08/2019 5:35
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