Novel H3K4me3 marks are enriched at human- and chimpanzee-specific cytogenetic structures.

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Serval ID
serval:BIB_20CA18A8E573
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Novel H3K4me3 marks are enriched at human- and chimpanzee-specific cytogenetic structures.
Journal
Genome Research
Author(s)
Giannuzzi G., Migliavacca E., Reymond A.
ISSN
1549-5469 (Electronic)
ISSN-L
1088-9051
Publication state
Published
Issued date
2014
Volume
24
Number
9
Pages
1455-1468
Language
english
Abstract
Human and chimpanzee genomes are 98.8% identical within comparable sequences. However, they differ structurally in nine pericentric inversions, one fusion that originated human chromosome 2, and content and localization of heterochromatin and lineage-specific segmental duplications. The possible functional consequences of these cytogenetic and structural differences are not fully understood and their possible involvement in speciation remains unclear. We show that subtelomeric regions-regions that have a species-specific organization, are more divergent in sequence, and are enriched in genes and recombination hotspots-are significantly enriched for species-specific histone modifications that decorate transcription start sites in different tissues in both human and chimpanzee. The human lineage-specific chromosome 2 fusion point and ancestral centromere locus as well as chromosome 1 and 18 pericentric inversion breakpoints showed enrichment of human-specific H3K4me3 peaks in the prefrontal cortex. Our results reveal an association between plastic regions and potential novel regulatory elements.
Pubmed
Web of science
Open Access
Yes
Create date
26/09/2014 9:45
Last modification date
20/08/2019 13:57
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