Qualitative platelet defect and thrombohaemorrhagic complications in a patient with polycythaemia vera. Case 10.

Details

Serval ID
serval:BIB_20C1BFC3854E
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Qualitative platelet defect and thrombohaemorrhagic complications in a patient with polycythaemia vera. Case 10.
Journal
Hämostaseologie
Author(s)
Friess D., Lämmle B., Alberio L.
ISSN
0720-9355 (Print)
ISSN-L
0720-9355
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
23
Number
3
Pages
138-143
Language
english
Notes
Publication types: Case Reports ; Journal Article Publication Status: ppublish
Abstract
We describe a 67-year-old patient with polycythaemia vera and pathological functional platelet studies. He not only suffered a transient ischaemic attack despite taking of antiplatelet agents, but also showed bleeding diathesis with cerebral bleeding and spontaneous suffusions. Platelet function studies and clinical findings improved after phlebotomy and cytoreductive treatment with hydroxyurea. Thrombosis and haemorrhage account predominantly for morbidity and mortality in patients with polycythaemia vera. The pathophysiological mechanisms to explain thrombosis and bleeding in patients with myeloproliferative disorders including polycythaemia vera were intensively studied. However, up to now no clear correlation of laboratory findings in relation to clinical history of thrombosis and bleeding was demonstrated. In this report the most important pathophysiological mechanisms and therapy with antiplatelet agents are discussed.
Keywords
Aged, Aspirin/therapeutic use, Blood Platelet Disorders/blood, Blood Platelet Disorders/drug therapy, Hemorrhage/blood, Humans, Male, Platelet Aggregation, Platelet Aggregation Inhibitors/therapeutic use, Platelet Function Tests, Polycythemia Vera/blood, Polycythemia Vera/complications, Thrombosis/blood, Ticlopidine/analogs & derivatives, Ticlopidine/therapeutic use
Pubmed
Create date
10/02/2015 11:25
Last modification date
20/08/2019 12:57
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