Diagnostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography in gallbladder cancer: A meta-analysis.

Details

Serval ID
serval:BIB_20B8CE7AB470
Type
Article: article from journal or magazin.
Collection
Publications
Title
Diagnostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography in gallbladder cancer: A meta-analysis.
Journal
World journal of gastroenterology
Author(s)
Annunziata S., Pizzuto D.A., Caldarella C., Galiandro F., Sadeghi R., Treglia G.
ISSN
2219-2840 (Electronic)
ISSN-L
1007-9327
Publication state
Published
Issued date
28/10/2015
Peer-reviewed
Oui
Volume
21
Number
40
Pages
11481-11488
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Review
Publication Status: ppublish
Abstract
To meta-analyze published data about the diagnostic accuracy of fluorine-18-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) and PET/computed tomography (PET/CT) in the evaluation of primary tumor in patients with gallbladder cancer (GBCa).
A comprehensive literature search of studies published through 30(th) June 2014 regarding the role of (18)F-FDG PET and PET/CT in the evaluation of primary gallbladder cancer (GBCa) was performed. All retrieved studies were reviewed. Pooled sensitivity and specificity of (18)F-FDG PET or PET/CT in the evaluation of primary GBCa were calculated. The area under the summary receiving operator characteristics curve (AUC) was calculated to measure the accuracy of these methods. Sub-analyses considering the device used (PET vs PET/CT) were carried out.
Twenty-one studies comprising 495 patients who underwent (18)F-FDG PET or PET/CT for suspicious GBCa were selected for the systematic review. The meta-analysis of 13 selected studies provided the following results: sensitivity 87% (95%CI: 82%-92%), specificity 78% (95%CI: 68%-86%). The AUC was 0.88. Improvement of sensitivity and specificity was observed when PET/CT was used.
(18)F-FDG-PET and PET/CT demonstrated to be useful diagnostic imaging methods in the assessment of primary tumor in GBCa patients, nevertheless possible sources of false-negative and false-positive results should be kept in mind. PET/CT seems to have a better diagnostic accuracy than PET alone in this setting.

Keywords
Fluorodeoxyglucose F18, Gallbladder Neoplasms/diagnostic imaging, Humans, Multimodal Imaging, Positron-Emission Tomography, Predictive Value of Tests, Radiopharmaceuticals, Reproducibility of Results, Tomography, X-Ray Computed, Fluorine-18-fluorodeoxyglucose, Gallbladder cancer, Positron emission tomography, Positron emission tomography/computed tomography
Pubmed
Web of science
Open Access
Yes
Create date
20/08/2017 16:46
Last modification date
20/08/2019 12:57
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