The mzTab Data Exchange Format: Communicating Mass-spectrometry-based Proteomics and Metabolomics Experimental Results to a Wider Audience.

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Serval ID
serval:BIB_20AA0B90B470
Type
Article: article from journal or magazin.
Collection
Publications
Title
The mzTab Data Exchange Format: Communicating Mass-spectrometry-based Proteomics and Metabolomics Experimental Results to a Wider Audience.
Journal
Molecular and Cellular Proteomics
Author(s)
Griss J., Jones A.R., Sachsenberg T., Walzer M., Gatto L., Hartler J., Thallinger G.G., Salek R.M., Steinbeck C., Neuhauser N., Cox J., Neumann S., Fan J., Reisinger F., Xu Q.W., Del Toro N., Pérez-Riverol Y., Ghali F., Bandeira N., Xenarios I., Kohlbacher O., Vizcaíno J.A., Hermjakob H.
ISSN
1535-9484 (Electronic)
ISSN-L
1535-9476
Publication state
Published
Issued date
2014
Volume
13
Number
10
Pages
2765-2775
Language
english
Abstract
The HUPO Proteomics Standards Initiative has developed several standardized data formats to facilitate data sharing in mass spectrometry (MS)-based proteomics. These allow researchers to report their complete results in a unified way. However, at present, there is no format to describe the final qualitative and quantitative results for proteomics and metabolomics experiments in a simple tabular format. Many downstream analysis use cases are only concerned with the final results of an experiment and require an easily accessible format, compatible with tools such as Microsoft Excel or R. We developed the mzTab file format for MS-based proteomics and metabolomics results to meet this need. mzTab is intended as a lightweight supplement to the existing standard XML-based file formats (mzML, mzIdentML, mzQuantML), providing a comprehensive summary, similar in concept to the supplemental material of a scientific publication. mzTab files can contain protein, peptide, and small molecule identifications together with experimental metadata and basic quantitative information. The format is not intended to store the complete experimental evidence but provides mechanisms to report results at different levels of detail. These range from a simple summary of the final results to a representation of the results including the experimental design. This format is ideally suited to make MS-based proteomics and metabolomics results available to a wider biological community outside the field of MS. Several software tools for proteomics and metabolomics have already adapted the format as an output format. The comprehensive mzTab specification document and extensive additional documentation can be found online.
Pubmed
Web of science
Open Access
Yes
Create date
13/11/2014 9:28
Last modification date
20/08/2019 12:56
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