Pulmonary toxicity with mefloquine.

Details

Serval ID
serval:BIB_20971
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Pulmonary toxicity with mefloquine.
Journal
European Respiratory Journal
Author(s)
Udry E., Bailly F., Dusmet M., Schnyder P., Lemoine R., Fitting J.W.
ISSN
0903-1936
Publication state
Published
Issued date
2001
Volume
18
Number
5
Pages
890-892
Language
english
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish. PDF type: Case study
Abstract
This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy. Extensive microbiological investigation remained negative and video-assisted thoracoscopic lung biopsy demonstrated diffuse alveolar damage. The evolution was favourable without treatment. This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine. Glucose-6-phosphate dehydrogenase deficiency was present in the former case and was thought to contribute to the lung injury. However, glucose-phosphate dehydrogenase was normal in the present case, suggesting that it is not a predisposing condition to the lung injury.
Keywords
Antimalarials, Humans, Malaria, Falciparum, Male, Mefloquine, Middle Aged, Pulmonary Alveoli, Respiratory Distress Syndrome, Adult, Tomography, X-Ray Computed
Pubmed
Web of science
Create date
19/11/2007 12:16
Last modification date
20/08/2019 12:56
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