Organometallic cages as vehicles for intracellular release of photosensitizers.

Details

Serval ID
serval:BIB_2067413856B7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Organometallic cages as vehicles for intracellular release of photosensitizers.
Journal
Journal of the American Chemical Society
Author(s)
Schmitt F., Freudenreich J., Barry N.P., Juillerat-Jeanneret L., Süss-Fink G., Therrien B.
ISSN
1520-5126 (Electronic)
ISSN-L
0002-7863
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
134
Number
2
Pages
754-757
Language
english
Notes
Publication types: Journal Article
Abstract
Water-soluble metalla-cages were used to deliver hydrophobic porphin molecules to cancer cells. After internalization, the photosensitizer was photoactivated, significantly increasing the cytotoxicity in cells. During the transport, the photosensitizer remains nonreactive to light, offering a new strategy to tackle overall photosensitization, a limitation often encountered in photodynamic therapy.
Keywords
Drug Delivery Systems, HeLa Cells, Humans, Models, Molecular, Molecular Biology, Organometallic Compounds/chemistry, Photosensitizing Agents/administration & dosage, Photosensitizing Agents/chemistry, Porphyrins/chemistry, Porphyrins/pharmacology
Pubmed
Web of science
Create date
05/01/2012 11:12
Last modification date
20/08/2019 12:56
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