The very low risk of myocarditis and pericarditis after mRNA COVID-19 vaccination should not discourage vaccination.

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Ressource 1Download: Haaf_SMW_2021.pdf (1295.40 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-SA 4.0
Serval ID
serval:BIB_20655555269C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The very low risk of myocarditis and pericarditis after mRNA COVID-19 vaccination should not discourage vaccination.
Journal
Swiss medical weekly
Author(s)
Haaf P., Kuster G.M., Mueller C., Berger C.T., Monney P., Burger P., Stämpfli S.F., Attenhofer Jost C.H., Zellweger M.J., Osswald S., Donner B.C., Koestner S.C., Tanner F.C.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
11/10/2021
Peer-reviewed
Oui
Volume
151
Pages
w30087
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The benefits of vaccination - regarding COVID-19 infection and transmission, as well as COVID-associated complications - clearly outweigh the potential risk of vaccine-associated inflammation of the heart and other adverse events. Given the current state of knowledge, the outcome of myocarditis and pericarditis following vaccination is generally good. This review aims to guide physicians in the early diagnosis and management of suspected myocarditis following mRNA COVID vaccination. The initial work-up should include detailed history, a 12-lead electrocardiogram and serological biomarkers (high-sensitivity cardiac troponin T/I, natriuretic peptides and markers of inflammation) in accordance with the assessments recommended in current clinical practice guidelines for patients presenting with acute chest pain. In patients with suspected myocarditis, further assessment with transthoracic echocardiography and cardiovascular magnetic resonance imaging should be undertaken to confirm peri-/myocarditis and to distinguish the findings from other diseases with similar presentation. Patients with mRNA vaccine-associated myocarditis should be followed-up at least once to exclude chronic myocardial inflammation and deterioration of left ventricular ejection fraction. Consultation with an expert such as an immunologist with experience in vaccination regarding further mRNA vaccinations is advised in all patients with mRNA vaccine-associated perimyocarditis. Reporting of mRNA vaccine-associated myocarditis to Swissmedic is mandatory. Cohort studies prospectively follow-up on young adult and paediatric populations following immunisation with an mRNA COVID vaccine to monitor cardiac and immune parameters would generate valuable knowledge to better understand pathogenesis and risk factors for vaccine-associated perimyocarditis.
Pubmed
Open Access
Yes
Create date
25/10/2021 9:12
Last modification date
13/08/2022 7:08
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