Autoregulation of glucose production in health and disease

Details

Serval ID
serval:BIB_205B0BE753EB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Autoregulation of glucose production in health and disease
Journal
Current Opinion in Clinical Nutrition and Metabolic Care
Author(s)
Tappy  L., Chiolero  R., Berger  M.
ISSN
1363-1950 (Print)
Publication state
Published
Issued date
03/1999
Volume
2
Number
2
Pages
161-4
Notes
Journal Article
Review --- Old month value: Mar
Abstract
Plasma glucose concentration is a major regulator of glucose production in experimental animals and in humans. Hyperglycemia inhibits and hypoglycemia stimulates glucose production through mechanisms which are, in part, independent of changes in glucoregulatory hormones. Glucose production does not change when gluconeogenesis is acutely inhibited or stimulated. These observations indicate an autoregulatory process by which hepatic glucose production is altered as a direct consequence of changes in glycemia. Data obtained in patients with glucokinase gene mutations indicate that glucokinase may play a role in this regulatory process. Hyperglycemia in type 2 diabetic patients and in critically ill patients may result from a blunted effect of hyperglycemia on glucose production.
Keywords
Animals Blood Glucose/*metabolism Dogs Gluconeogenesis Homeostasis Humans Hyperglycemia/*blood Hypoglycemia/*blood Reference Values
Pubmed
Create date
24/01/2008 13:36
Last modification date
20/08/2019 12:56
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