Fixed rings and strictures in Eosinophilic Esophagitis develop due to continuing inflammation over time

Details

Serval ID
serval:BIB_20554D30B0C3
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Poster: Summary – with images – on one page of the results of a researche project. The summaries of the poster must be entered in "Abstract" and not "Poster".
Collection
Publications
Institution
Title
Fixed rings and strictures in Eosinophilic Esophagitis develop due to continuing inflammation over time
Title of the conference
Annual Meeting of the Swiss Society of Gastroenterology, Swiss Society of Visceral Surgery, Swiss Association of the Study of the Liver and Swiss Society of Clinical Nutrition
Author(s)
Schoepfer A., Safroneeva E., Bussmann C., Netzer P., Portmann S., Straumann A.
Address
Interlaken, Switzerland, September 20-21, 2012
ISBN
1424-7860
ISSN-L
0036-7672
Publication state
Published
Issued date
2012
Volume
142
Series
Swiss Medical Weekly
Pages
S10
Language
english
Abstract
Background and Aims: Two distinct e ndoscopic phenotypes
of E osinophilic Esophagitis (EoE) h ave been identified: t he
inflammatory (IP) a nd the stenosing (SP) p henotype. I t is not
known whether these EoE-associated phenotypes are reflective
of different phases during disease course. We aimed to assess
the phenotype a t initial EoE p resentation and d iagnosis and to
evaluate if SP increases over time.
Methods: R etrospective a nalysis of t he Swiss EoE Database
(SEED) extended b y a review of p atients charts, endoscopy
and pathology records.
Results: F orty-four E oE p atients were a nalyzed (33 males,
mean age at index visit 41 ± 14 years, all Caucasians). Median
follow-up t ime was 3.1 years (IQR 1-4, r ange 1 -18 years).
Median diagnostic delay w as 5 y ears (IQR 2-16, range 0-34
years). A t first diagnosis, 3 2% ( 14/44) o f EoE patients h ad
already presented w ith a stenosis. T he mean d iameter o f the
stenoses w as 1 0 ± 2 mm, and the mean length was 2 .8 ± 2 .9
cm. Peak e osinophil count d id n ot c hange over t ime (48 ± 39
eos/HPF at index visit vs. 59 ± 41 eos/HPF at end of follow-up,
n=44). The risk of the presence of a stenosis at index visit was
0% f or a d isease duration of 0 -4 y ears, 37% f or a d isease
duration between 5-10 years and 67% f or a d isease duration
>10 years (p = 0.0035, trend test).
Conclusions: T he frequency of e sophageal stenoses i s
proportional to the disease duration, whereas the inflammatory
activity does n ot s ignificantly c hange over t ime. O ur f indings
underscore the necessity to reduce diagnostic delay in EoE and
to control the underlying inflammatory processes to prevent
esophageal remodeling.
Create date
14/02/2013 16:37
Last modification date
20/08/2019 12:56
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