Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.

Details

Serval ID
serval:BIB_20387
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.
Journal
Journal of Medicinal Chemistry
Author(s)
Brühlmann C., Ooms F., Carrupt P.A., Testa B., Catto M., Leonetti F., Altomare C., Carotti A.
ISSN
0022-2623
Publication state
Published
Issued date
2001
Volume
44
Number
19
Pages
3195-3198
Language
english
Notes
Publication types: Journal Article
Abstract
A set of 17 coumarin and 2 chromone derivatives with known inhibitory activity toward monoamine oxidase (MAO) A and B were tested as acetylcholinesterase (AChE) inhibitors. All compounds inhibited AChE with values in the micromolar range (3-100 microM). A kinetic study showed that most compounds acted as noncompetitive AChE inhibitors. This finding may be of interest in the context of Alzheimer's disease because recent observations suggest that MAO and AChE inhibition might decrease beta-amyloid deposition.
Keywords
Acetylcholinesterase/chemistry, Animals, Cholinesterase Inhibitors/chemical synthesis, Cholinesterase Inhibitors/chemistry, Coumarins/chemical synthesis, Coumarins/chemistry, Eels, Monoamine Oxidase Inhibitors/chemical synthesis, Monoamine Oxidase Inhibitors/chemistry, Structure-Activity Relationship
Pubmed
Create date
19/11/2007 9:43
Last modification date
20/08/2019 12:56
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