Astrocyte-specific expression of aquaporin-9 in mouse brain is increased after transient focal cerebral ischemia

Details

Serval ID
serval:BIB_20319657D167
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Astrocyte-specific expression of aquaporin-9 in mouse brain is increased after transient focal cerebral ischemia
Journal
Journal of Cerebral Blood Flow and Metabolism
Author(s)
Badaut  J., Hirt  L., Granziera  C., Bogousslavsky  J., Magistretti  P. J., Regli  L.
ISSN
0271-678X (Print)
Publication state
Published
Issued date
05/2001
Peer-reviewed
Oui
Volume
21
Number
5
Pages
477-82
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
Aquaporin-9 (AQP9) is a new member of the aquaporin family of water-selective channels mainly expressed in liver and testis, presenting the characteristic of also being permeable to various solutes, particularly lactate. Recent data have shown the presence of AQP9 on tanycytes in the rat brain. In the current study, the authors show the expression of AQP9 in astrocytes in the mouse brain and changes in its expression after cerebral ischemia. Indeed, in control mouse, the AQP9 immunolabeling is present on astrocytic processes bordering the subarachnoid space and ventricles. The labeling also is observed on astrocytes in the white matter, hippocampus, hypothalamus, and lateral septum. After focal transient ischemia, an increase of the immunolabeling is detected on astrocytes in periinfarct areas. This AQP9 distribution study in mouse brain suggests a role of AQP9 in water homeostasis in the central nervous system. Furthermore, the overexpression of AQP9 on astrocytes surrounding an ischemic lesion suggests that AQP9 may also play a role in the regulation of postischemia edema and, in view of its permeability to monocarboxylates, in the clearance of lactate from the ischemic focus.
Keywords
Animals Aquaporins/analysis/*metabolism Astrocytes/*metabolism Blotting, Western Brain/*metabolism Brain Chemistry Fluorescent Antibody Technique Immunohistochemistry Kinetics Liver/chemistry Male Mice Testis/chemistry Vasospasm, Intracranial/*metabolism
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 12:40
Last modification date
20/08/2019 12:56
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