Sub-cortical and brainstem sites associated with chemo-stimulated increases in ventilation in humans.

Details

Serval ID
serval:BIB_20194BD1C287
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sub-cortical and brainstem sites associated with chemo-stimulated increases in ventilation in humans.
Journal
NeuroImage
Author(s)
McKay L.C., Critchley H.D., Murphy K., Frackowiak R.S., Corfield D.R.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Publication state
Published
Issued date
01/02/2010
Peer-reviewed
Oui
Volume
49
Number
3
Pages
2526-2535
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
We investigated the neural basis for spontaneous chemo-stimulated increases in ventilation in awake, healthy humans. Blood oxygen level dependent (BOLD) functional MRI was performed in nine healthy subjects using T2 weighted echo planar imaging. Brain volumes (52 transverse slices, cortex to high spinal cord) were acquired every 3.9 s. The 30 min paradigm consisted of six, 5-min cycles, each cycle comprising 45 s of hypoxic-isocapnia, 45 s of isooxic-hypercapnia and 45 s of hypoxic-hypercapnia, with 55 s of non-stimulatory hyperoxic-isocapnia (control) separating each stimulus period. Ventilation was significantly (p<0.001) increased during hypoxic-isocapnia, isooxic-hypercapnia and hypoxic-hypercapnia (17.0, 13.8, 24.9 L/min respectively) vs. control (8.4 L/min) and was associated with significant (p<0.05, corrected for multiple comparisons) signal increases within a bilateral network that included the basal ganglia, thalamus, red nucleus, cerebellum, parietal cortex, cingulate and superior mid pons. The neuroanatomical structures identified provide evidence for the spontaneous control of breathing to be mediated by higher brain centres, as well as respiratory nuclei in the brainstem.

Keywords
Adult, Brain/physiology, Brain Mapping, Carbon Dioxide/blood, Female, Humans, Hypercapnia/physiopathology, Hypoxia/physiopathology, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Mass Spectrometry, Oxygen/blood, Pulmonary Ventilation/physiology, Signal Processing, Computer-Assisted, Young Adult
Pubmed
Web of science
Create date
02/02/2010 11:58
Last modification date
20/08/2019 12:56
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