Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord.

Details

Serval ID
serval:BIB_2000F9859DAE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord.
Journal
Nature communications
Author(s)
Greiner N., Barra B., Schiavone G., Lorach H., James N., Conti S., Kaeser M., Fallegger F., Borgognon S., Lacour S., Bloch J., Courtine G., Capogrosso M.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
19/01/2021
Peer-reviewed
Oui
Volume
12
Number
1
Pages
435
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Epidural electrical stimulation (EES) of lumbosacral sensorimotor circuits improves leg motor control in animals and humans with spinal cord injury (SCI). Upper-limb motor control involves similar circuits, located in the cervical spinal cord, suggesting that EES could also improve arm and hand movements after quadriplegia. However, the ability of cervical EES to selectively modulate specific upper-limb motor nuclei remains unclear. Here, we combined a computational model of the cervical spinal cord with experiments in macaque monkeys to explore the mechanisms of upper-limb motoneuron recruitment with EES and characterize the selectivity of cervical interfaces. We show that lateral electrodes produce a segmental recruitment of arm motoneurons mediated by the direct activation of sensory afferents, and that muscle responses to EES are modulated during movement. Intraoperative recordings suggested similar properties in humans at rest. These modelling and experimental results can be applied for the development of neurotechnologies designed for the improvement of arm and hand control in humans with quadriplegia.
Keywords
Afferent Pathways/physiopathology, Animals, Cervical Cord/cytology, Cervical Cord/diagnostic imaging, Cervical Cord/injuries, Cervical Cord/physiopathology, Computer Simulation, Disease Models, Animal, Electrodes, Implanted, Epidural Space, Female, Ganglia, Spinal/cytology, Ganglia, Spinal/diagnostic imaging, Ganglia, Spinal/physiopathology, Humans, Macaca fascicularis, Magnetic Resonance Imaging, Male, Models, Neurological, Motor Neurons/physiology, Muscle, Skeletal/innervation, Quadriplegia/etiology, Quadriplegia/physiopathology, Quadriplegia/therapy, Recruitment, Neurophysiological/physiology, Spinal Cord Injuries/complications, Spinal Cord Injuries/diagnosis, Spinal Cord Injuries/physiopathology, Spinal Cord Injuries/therapy, Spinal Cord Stimulation/instrumentation, Spinal Cord Stimulation/methods, Upper Extremity/innervation
Pubmed
Web of science
Open Access
Yes
Create date
26/01/2021 13:16
Last modification date
08/07/2021 6:37
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