What is the physiological role of hypothalamic tanycytes in metabolism?

Details

Serval ID
serval:BIB_1FBCFCE4FB55
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
What is the physiological role of hypothalamic tanycytes in metabolism?
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
Author(s)
Bolborea M., Langlet F.
ISSN
1522-1490 (Electronic)
ISSN-L
0363-6119
Publication state
Published
Issued date
01/06/2021
Peer-reviewed
Oui
Volume
320
Number
6
Pages
R994-R1003
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
In vertebrates, the energy balance process is tightly controlled by complex neural circuits that sense metabolic signals and adjust food intake and energy expenditure in line with the physiological requirements of optimal conditions. Within neural networks controlling energy balance, tanycytes are peculiar ependymoglial cells that are nowadays recognized as multifunctional players in the metabolic hypothalamus. However, the physiological function of hypothalamic tanycytes remains unclear, creating a number of ambiguities in the field. Here, we review data accumulated over the years that demonstrate the physiological function of tanycytes in the maintenance of metabolic homeostasis, opening up new research avenues. The presumed involvement of tanycytes in the pathophysiology of metabolic disorders and age-related neurodegenerative diseases will be finally discussed.
Keywords
Energy balance, Glia-Neuron communication, Glucose homeostasis, Hypothalamus, Tanycyte, energy balance, glia-neuron communication, glucose homeostasis, hypothalamus, tanycyte
Pubmed
Web of science
Open Access
Yes
Create date
12/04/2021 12:01
Last modification date
13/08/2021 6:39
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