European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents.

Details

Serval ID
serval:BIB_1FB2E13A9D8C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents.
Journal
European child & adolescent psychiatry
Author(s)
Schrag A., Martino D., Apter A., Ball J., Bartolini E., Benaroya-Milshtein N., Buttiglione M., Cardona F., Creti R., Efstratiou A., Gariup M., Georgitsi M., Hedderly T., Heyman I., Margarit I., Mir P., Moll N., Morer A., Müller N., Müller-Vahl K., Münchau A., Orefici G., Plessen K.J., Porcelli C., Paschou P., Rizzo R., Roessner V., Schwarz M.J., Steinberg T., Tagwerker Gloor F., Tarnok Z., Walitza S., Dietrich A., Hoekstra P.J.
Working group(s)
EMTICS Collaborative Group
Contributor(s)
Anastasiou Z., Apter A., Baglioni V., Ball J., Bartolini E., Benaroya-Milshtein N., Bodmer B., Bognar E., Burger B., Buse J., Buttiglione M., Cardona F., Correa Vela M., Creti R., Dietrich A., Debes N.M., Efstratiou A., Ferro M.C., Fremer C., Garcia-Delgar B., Gariup M., Georgitsi M., Gulisano M., Hagen A., Hagstrøm J., Hedderly T.J., Heyman I., Hoekstra P.J., Huyser C., Imperi M., Karagiannidis I., Laviola G., Macri S., Madruga-Garrido M., Margarit I., Marotta A., Martino D., Meier U.C., Mir P., Moll N., Morer A., Müller N., Müller-Vahl K., Münchau A., Nagy P., Neri V., Openneer TJC, Orefici G., Paschou P., Pellico A., Petruzzelli O., Plessen K.J., Porcelli C., Redondo M., Rizzo R., Roazzi P., Roessner V., Ruhrman D., Schnell JML, Schrag A., Schütze G.A., Schwarz M.J., Silvestri P.R., Skov L., Steinberg T., Stöber S., Gloor F.T., Tallon M., Tarnok Z., Turner V.L., Walitza S., Weidinger E., Woods M.L.
ISSN
1435-165X (Electronic)
ISSN-L
1018-8827
Publication state
Published
Issued date
01/2019
Peer-reviewed
Oui
Volume
28
Number
1
Pages
91-109
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Abstract
Genetic predisposition, autoimmunity and environmental factors [e.g. pre- and perinatal difficulties, Group A Streptococcal (GAS) and other infections, stress-inducing events] might interact to create a neurobiological vulnerability to the development of tics and associated behaviours. However, the existing evidence for this relies primarily on small prospective or larger retrospective population-based studies, and is therefore still inconclusive. This article describes the design and methodology of the EMTICS study, a longitudinal observational European multicentre study involving 16 clinical centres, with the following objectives: (1) to investigate the association of environmental factors (GAS exposure and psychosocial stress, primarily) with the onset and course of tics and/or obsessive-compulsive symptoms through the prospective observation of at-risk individuals (ONSET cohort: 260 children aged 3-10 years who are tic-free at study entry and have a first-degree relative with a chronic tic disorder) and affected individuals (COURSE cohort: 715 youth aged 3-16 years with a tic disorder); (2) to characterise the immune response to microbial antigens and the host's immune response regulation in association with onset and exacerbations of tics; (3) to increase knowledge of the human gene pathways influencing the pathogenesis of tic disorders; and (4) to develop prediction models for the risk of onset and exacerbations of tic disorders. The EMTICS study is, to our knowledge, the largest prospective cohort assessment of the contribution of different genetic and environmental factors to the risk of developing tics in putatively predisposed individuals and to the risk of exacerbating tics in young individuals with chronic tic disorders.
Keywords
Adolescent, Child, Child, Preschool, Cohort Studies, Europe, Female, Genetic Predisposition to Disease, Humans, Male, Risk Factors, Tic Disorders/complications, Tic Disorders/diagnosis, Tic Disorders/pathology, Genetics, Longitudinal, Obsessive–compulsive disorder, Streptococcal infection, Stress, Tourette syndrome
Pubmed
Web of science
Open Access
Yes
Create date
16/07/2018 10:38
Last modification date
20/08/2019 12:55
Usage data