Frequency and risk factors for extraintestinal manifestations in the Swiss inflammatory bowel disease cohort.

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State: Public
Version: author
Serval ID
serval:BIB_1F821DB55859
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Frequency and risk factors for extraintestinal manifestations in the Swiss inflammatory bowel disease cohort.
Journal
American Journal of Gastroenterology
Author(s)
Vavricka S.R., Brun L., Ballabeni P., Pittet V., Prinz Vavricka B.M., Zeitz J., Rogler G., Schoepfer A.M.
ISSN
1572-0241[electronic], 0002-9270[linking]
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
106
Number
1
Pages
110-119
Language
english
Abstract
OBJECTIVES: Data on the frequency of extraintestinal manifestations (EIMs) in Crohn's disease (CD) and ulcerative colitis (UC) and analyses of their risk factors are scarce. We evaluated their prevalence and risk factors in a large nationwide cohort of inflammatory bowel disease (IBD) patients.
METHODS: IBD patients from an adult clinical cohort in Switzerland (Swiss IBD cohort study) were prospectively included. Data from validated physician enrolment questionnaires were analyzed.
RESULTS: A total of 950 patients were included, 580 (61%) with CD (mean age 41 years) and 370 (39%) with UC (mean age 42 years). Of these, 249 (43%) of CD and 113 (31%) of UC patients had one to five EIMs. The following EIMs were found: arthritis (CD 33%, UC 21%), aphthous stomatitis (CD 10%, UC 4%), uveitis (CD 6%, UC 4%), erythema nodosum (CD 6%, UC 3%), ankylosing spondylitis (CD 6%, UC 2%), psoriasis (CD 2%, UC 1%), pyoderma gangrenosum (CD and UC each 2%), and primary sclerosing cholangitis (CD 1%, UC 4%). Multiple logistic regression identified the following risk factors for ongoing EIM in CD: active disease (odds ratio (OR)=1.95, 95% confidence interval (CI)=1.17-3.23, P=0.01), and positive IBD family history (OR=1.77, 95% CI=1.07-2.92, P=0.025). No risk factors were identified in UC patients.
CONCLUSIONS: EIMs are a frequent problem in CD and UC patients. Active disease and positive IBD family history are associated with ongoing EIM in CD patients. Identification of EIM prevalence and associated risk factors may result in increased awareness for this problem and thereby facilitating their diagnosis and therapeutic management.
Keywords
Colitis, Ulcerative/diagnosis , Colitis, Ulcerative/epidemiology , Crohn Disease/diagnosis , Crohn Disease/epidemiology , Switzerland
Pubmed
Web of science
Create date
01/02/2011 15:51
Last modification date
26/07/2020 7:08
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