Ubiquitin- and ubiquitin-like proteins-conjugating enzymes (E2s) in breast cancer.

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Ressource 1Download: serval:BIB_1F77C142E958.P001 (427.35 [Ko])
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Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_1F77C142E958
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ubiquitin- and ubiquitin-like proteins-conjugating enzymes (E2s) in breast cancer.
Journal
Molecular Biology Reports
Author(s)
Voutsadakis I.A.
ISSN
1573-4978 (Electronic)
ISSN-L
0301-4851
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
40
Number
2
Pages
2019-2034
Language
english
Notes
Publication types: Journal Article
Abstract
Breast cancer is the most common malignancy in women and a significant cause of morbidity and mortality. Sub-types of breast cancer defined by the expression of steroid hormones and Her2/Neu oncogene have distinct prognosis and undergo different therapies. Besides differing in their phenotype, sub-types of breast cancer display various molecular lesions that participate in their pathogenesis. BRCA1 is one of the common hereditary cancer predisposition genes and encodes for an ubiquitin ligase. Ubiquitin ligases or E3 enzymes participate together with ubiquitin activating enzyme and ubiquitin conjugating enzymes in the attachment of ubiquitin (ubiquitination) in target proteins. Ubiquitination is a post-translational modification regulating multiple cell functions. It also plays important roles in carcinogenesis in general and in breast carcinogenesis in particular. Ubiquitin conjugating enzymes are a central component of the ubiquitination machinery and are often perturbed in breast cancer. This paper will discuss ubiquitin and ubiquitin-like proteins conjugating enzymes participating in breast cancer pathogenesis, their relationships with other proteins of the ubiquitination machinery and their role in phenotype of breast cancer sub-types.
Pubmed
Web of science
Open Access
Yes
Create date
07/02/2013 17:55
Last modification date
01/10/2019 6:17
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