Ontogeny of ependymoglial cells lining the third ventricle in mice.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_1F6B14DBD019
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ontogeny of ependymoglial cells lining the third ventricle in mice.
Journal
Frontiers in endocrinology
Author(s)
Lopez-Rodriguez D., Rohrbach A., Lanzillo M., Gervais M., Croizier S., Langlet F.
ISSN
1664-2392 (Print)
ISSN-L
1664-2392
Publication state
Published
Issued date
2022
Peer-reviewed
Oui
Volume
13
Pages
1073759
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
During hypothalamic development, the germinative neuroepithelium gives birth to diverse neural cells that regulate numerous physiological functions in adulthood.
Here, we studied the ontogeny of ependymal cells in the mouse mediobasal hypothalamus using the BrdU approach and publicly available single-cell RNAseq datasets.
We observed that while typical ependymal cells are mainly produced at E13, tanycyte birth depends on time and subtypes and lasts up to P8. Typical ependymocytes and β tanycytes are the first to arise at the top and bottom of the dorsoventral axis around E13, whereas α tanycytes emerge later in development, generating an outside-in dorsoventral gradient along the third ventricle. Additionally, α tanycyte generation displayed a rostral-to-caudal pattern. Finally, tanycytes mature progressively until they reach transcriptional maturity between P4 and P14.
Altogether, this data shows that ependyma generation differs in time and distribution, highlighting the heterogeneity of the third ventricle.
Keywords
Mice, Animals, Ependymoglial Cells, Third Ventricle, Neuroglia, Neurons, Neurogenesis, BrdU, ependymal cells, hypothalamic development, scRNAseq, tanycytes, third ventricle
Pubmed
Web of science
Open Access
Yes
Create date
31/01/2023 16:43
Last modification date
03/08/2023 7:08
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