Fluctuation of the SP/non-SP phenotype in the C6 glioma cell line
Details
Serval ID
serval:BIB_1F294192A519
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fluctuation of the SP/non-SP phenotype in the C6 glioma cell line
Journal
FEBS Lett
ISSN
0014-5793 (Print)
ISSN-L
0014-5793
Publication state
Published
Issued date
2007
Volume
581
Number
7
Pages
1435-40
Language
english
Notes
Platet, Nadine
Mayol, Jean-Francois
Berger, Francois
Herodin, Francis
Wion, Didier
eng
Research Support, Non-U.S. Gov't
England
2007/03/17
FEBS Lett. 2007 Apr 3;581(7):1435-40. doi: 10.1016/j.febslet.2007.02.071. Epub 2007 Mar 7.
Mayol, Jean-Francois
Berger, Francois
Herodin, Francis
Wion, Didier
eng
Research Support, Non-U.S. Gov't
England
2007/03/17
FEBS Lett. 2007 Apr 3;581(7):1435-40. doi: 10.1016/j.febslet.2007.02.071. Epub 2007 Mar 7.
Abstract
Using the C6 glioma cell as a paradigm, we found that (i) the clonogenicity of C6 cells is several orders of magnitude higher than the percentage of SP cells; (ii) non-SP cells are able to generate SP cells, and conversely SP cells generate non-SP cells; (iii) non-SP sorted cells behave as tumorigenic cells. Hence, in C6 cells cultured in serum-containing medium, SP cells can be generated from non-SP cells. This dynamic equilibrium explains in C6 cells the maintenance of the SP phenotype with cell passaging and demonstrates the existence of tumorigenic non-SP cells.
Keywords
ATP Binding Cassette Transporter, Subfamily G, Member 2, ATP-Binding Cassette Transporters/analysis/metabolism, Animals, Cell Line, Tumor/metabolism/*pathology, Cell Transformation, Neoplastic/metabolism/*pathology, Clone Cells/metabolism/pathology, Glioma/metabolism/*pathology, Phenotype, Rats
Pubmed
Create date
02/05/2024 10:41
Last modification date
28/05/2024 7:09
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