Anecortave acetate treatment for retinal angiomatous proliferation: a pilot study.

Details

Serval ID
serval:BIB_1EB2ACE7186F
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Anecortave acetate treatment for retinal angiomatous proliferation: a pilot study.
Journal
Retina
Author(s)
Klais C.M., Eandi C.M., Ober M.D., Sorenson J.A., Sadeghi S.N., Freund K.B., Spaide R.F., Slakter J.S., Yannuzzi L.A.
ISSN
0275-004X (Print)
ISSN-L
0275-004X
Publication state
Published
Issued date
09/2006
Peer-reviewed
Oui
Volume
26
Number
7
Pages
773-779
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The purpose of this study was to evaluate anecortave acetate treatment of retinal angiomatous proliferation (RAP), a neovascular form of age-related macular degeneration, with specific regard to inhibition of neovascularization and maintenance of vision.
Thirty-four patients with RAP with any stage of neovascularization were randomized 1:1:1 for treatment with three different quantities (30 mg, 15 mg, 3 mg) of anecortave acetate sterile suspension for juxtascleral administration. Best-corrected visual acuity (Early Treatment Diabetic Retinopathy Study chart), intraocular pressure measurement, biomicroscopy, funduscopy, digital fluorescein, and indocyanine green angiography were recorded at baseline and at 3 months. A 6-month retreatment interval was established for this study with a follow-up of 12 months. In selected patients optical coherence tomography was performed. The outcomes were mean changes in visual acuity and lesion size at 1 year.
The detachment of the neurosensory retina and retinal pigment epithelium improved in all eyes, but all neovascular lesions increased in size. Vision loss occurred in the majority of study eyes (22 out of 34 eyes, 64.7%) independent of the concentration administered.
The results suggest that a posterior juxtascleral injection of anecortave acetate reduces capillary permeability in patients with RAP. However, in spite of improvement of the exudation there is a progression of neovascularization and a significant loss of vision in all these patients. Like other monotherapeutic methods used to treat this variant of neovascular age-related macular degeneration, anecortave acetate alone does not appear to benefit these patients. Future studies should investigate a combination form of therapy.
Keywords
Aged, Aged, 80 and over, Angiogenesis Inhibitors/therapeutic use, Angiomatosis/drug therapy, Coloring Agents, Female, Fluorescein Angiography, Humans, Indocyanine Green, Injections, Intraocular Pressure, Macular Degeneration/drug therapy, Male, Pilot Projects, Pregnadienediols/therapeutic use, Prospective Studies, Retinal Neovascularization/drug therapy, Retinal Vessels/drug effects, Tomography, Optical Coherence, Visual Acuity
Pubmed
Web of science
Create date
11/03/2021 19:56
Last modification date
26/03/2021 6:35
Usage data