Aspirin use for the primary prevention of coronary heart disease: a population-based study in Switzerland.

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State: Public
Version: author
Serval ID
serval:BIB_1EB066A9E0D4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Aspirin use for the primary prevention of coronary heart disease: a population-based study in Switzerland.
Journal
Preventive Medicine
Author(s)
Rodondi Nicolas, Cornuz Jacques, Marques-Vidal Pedro M., Butler Javed, Hayoz Daniel, Pécoud Alain, Paccaud Fred, Waeber Gérard, Vollenweider Peter
ISSN
0091-7435
ISSN-L
0091-7435
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
46
Number
2
Pages
137-144
Language
english
Abstract
OBJECTIVE: To determine the patterns of aspirin use for the primary prevention of coronary heart disease (CHD). Aspirin for primary prevention has a more favorable risk/benefit profile among adults with high CHD risk than among low-risk adults. METHOD: We studied 5725 adults aged 35-75 without cardiovascular disease in a population-based study in Switzerland in 2003-2006. We examined regular aspirin use for cardiovascular prevention according to 10-year CHD risk and other cardiovascular risk factors. RESULTS: One hundred seventy-four participants used aspirin. Aspirin use increased with 10-year CHD risk, from 2.6% in persons with risk <6% (low risk) to 9% in those with risk 6-20% (intermediate risk, p=0.001), but no adults with risk >/=20% used aspirin. Participants with cardiovascular risk factors were more likely to use aspirin. However, 1.9% adults with risk <6% and no diabetes used aspirin. Using a population perspective, a more appropriate aspirin use would reduce up to 2,348/24,310 CHD deaths expected over 10 years in Switzerland, and avoid about 700 gastrointestinal bleedings and hemorrhagic strokes among those not eligible. CONCLUSION: Individuals at intermediate CHD risk and diabetics are more likely to take aspirin, but there are significant opportunities for improvement. The underuse of aspirin for those at risk coexists with an overuse among those at low risk.
Keywords
Adult, Aged, Aspirin/administration & dosage, Aspirin/therapeutic use, Coronary Disease/drug therapy, Coronary Disease/prevention & control, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Platelet Aggregation Inhibitors/administration & dosage, Platelet Aggregation Inhibitors/therapeutic use, Primary Prevention/methods, Switzerland , Colaus Study
Pubmed
Web of science
Create date
29/01/2008 15:56
Last modification date
21/06/2020 7:08
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