Atrial arrhythmias in adults with congenital heart disease.

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State: Public
Version: author
Serval ID
serval:BIB_1E896E6D28A0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Atrial arrhythmias in adults with congenital heart disease.
Journal
Circulation
Author(s)
Bouchardy J., Therrien J., Pilote L., Ionescu-Ittu R., Martucci G., Bottega N., Marelli A.J.
ISSN
1524-4539 (Electronic)
ISSN-L
0009-7322
Publication state
Published
Issued date
2009
Volume
120
Number
17
Pages
1679-1686
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
BACKGROUND: Atrial arrhythmias increase disease burden in the general adult population. Adults with congenital heart lesions constitute a rapidly growing group of patients with cardiovascular disease. We hypothesized that atrial arrhythmias increase with age and impair health outcomes in this population.
METHODS AND RESULTS: We conducted a population-based analysis of prevalence, lifetime risk, mortality, and morbidity associated with atrial arrhythmias in adults with congenital heart disease from l983 to 2005. In 38 428 adults with congenital heart disease in 2005, 5812 had atrial arrhythmias. Overall, the 20-year risk of developing atrial arrhythmia was 7% in a 20-year-old subject and 38% in a 50-year-old subject. More than 50% of patients with severe congenital heart disease reaching age 18 years developed atrial arrhythmias by age 65 years. In patients with congenital heart disease, the hazard ratio of any adverse event in those with atrial arrhythmias compared with those without was 2.50 (95% confidence interval, 2.38 to 2.62; P<0.0001), with a near 50% increase in mortality (hazard ratio, 1.47; 95% confidence interval, 1.37 to 1.58; P<0.001), more than double the risk of morbidity (stroke or heart failure) (hazard ratio, 2.21; 95% confidence interval, 2.07 to 2.36; P<0.001), and 3 times the risk of cardiac interventions (hazard ratio, 3.00; 95% confidence interval, 2.81 to 3.20; P<0.001).
CONCLUSIONS: Atrial arrhythmias occurred in 15% of adults with congenital heart disease. The lifetime incidence increased steadily with age and was associated with a doubling of the risk of adverse events. An increase in resource allocation should be anticipated to deal with this increasing burden.
Keywords
Adult, Age Factors, Aged, Atrial Fibrillation/epidemiology, Atrial Fibrillation/etiology, Cohort Studies, Female, Follow-Up Studies, Heart Defects, Congenital/complications, Heart Defects, Congenital/epidemiology, Humans, Male, Middle Aged, Population Surveillance, Retrospective Studies, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
05/06/2014 15:45
Last modification date
17/06/2020 7:08
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