Tumor treating fields: a novel treatment modality and its use in brain tumors.

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State: Public
Version: Final published version
Serval ID
serval:BIB_1E5E2F0B2497
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Tumor treating fields: a novel treatment modality and its use in brain tumors.
Journal
Neuro-oncology
Author(s)
Hottinger A.F., Pacheco P., Stupp R.
ISSN
1523-5866 (Electronic)
ISSN-L
1522-8517
Publication state
Published
Issued date
10/2016
Peer-reviewed
Oui
Volume
18
Number
10
Pages
1338-1349
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Tumor treating fields (TTFields) are low-intensity electric fields alternating at an intermediate frequency (200kHz), which have been demonstrated to block cell division and interfere with organelle assembly. This novel treatment modality has shown promise in a variety of tumor types. It has been evaluated in randomized phase 3 trials in glioblastoma (GBM) and demonstrated to prolong progression-free survival (PFS) and overall survival (OS) when administered together with standard maintenance temozolomide (TMZ) chemotherapy in patients with newly diagnosed GBM. TTFields are continuously delivered by 4 transducer arrays consisting each of 9 insulated electrodes that are placed on the patient's shaved scalp and connected to a portable device. Here we summarize the preclinical data and mechanism of action, the available clinical data, and further outlook of this treatment modality in brain tumors and other cancer indications.

Keywords
Animals, Brain Neoplasms/therapy, Electric Stimulation Therapy/methods, Electric Stimulation Therapy/trends, Glioblastoma/therapy, Humans
Pubmed
Web of science
Open Access
Yes
Create date
29/09/2016 17:46
Last modification date
20/08/2019 12:54
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