Circadian variation of ticagrelor-induced platelet inhibition in healthy adulty.

Details

Serval ID
serval:BIB_1E4335C184EE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Circadian variation of ticagrelor-induced platelet inhibition in healthy adulty.
Journal
European heart journal. Cardiovascular pharmacotherapy
Author(s)
Fournier S., Guenat F., Fournier A., Alberio L., Bonny O., Bertaggia Calderara D., Bardy D., Lauriers N., Harbaoui B., Monney P., Pascale P., Eeckhout E., Muller O.
ISSN
2055-6845 (Electronic)
Publication state
Published
Issued date
01/07/2018
Peer-reviewed
Oui
Volume
4
Number
3
Pages
166-171
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The circadian variation of platelet aggregation is well demonstrated. However, whether this has an impact on antiplatelet inhibition therapy is poorly documented. We aimed to observe whether ticagrelor-induced platelet inhibition follows a circadian rhythm.
The study included 25 healthy volunteers (11 female; 14 male). Blood samples were collected every 4 h. Ticagrelor was added in vitro at a concentration that provided 50% inhibition of the maximum response using the VerifyNow System Platelet Reactivity Test® thus avoiding any bias induced by circadian gastrointestinal absorption. Platelet aggregation testing was subsequently performed using the VerifyNow. Circadian changes in total platelet count, percentage of platelets inhibition, Von Willebrand activity, and volunteers' physiological parameters were analysed by fitting individuals' data to a sine curve with a 24-h period. Volunteers' physiological parameters [heart rate (b.p.m.), systolic/diastolic blood pressure (mmHg), and body temperature (Celsius)] followed a significant mean circadian pattern of 6 b.p.m. (P < 0.001), 5 mmHg/7 mmHg (P < 0.002), and 0.3°C (P < 0.001), respectively. Ticagrelor-induced platelet inhibition was significantly lower at 13:00 (38.4%) than at any other time (45.2%) (P = 0.018). Percentage of inhibited platelets plotted against time followed a circadian rhythm (P < 0.001), with mean minimum/maximum values at 13:00/02:00, respectively. Von Willebrand activity also followed a circadian pattern (P < 0.001), with an amplitude of 12.24% and a maximum activity at 12:00.
Ticagrelor-induced platelet inhibition follows a circadian rhythm, with the lowest mean values achieved at 13:00. These results deserve further studies in patients with coronary artery disease.
Keywords
Adult, Circadian Rhythm, Female, Healthy Volunteers, Humans, Male, Platelet Aggregation/drug effects, Platelet Aggregation Inhibitors/pharmacology, Ticagrelor/pharmacology, Time Factors, Young Adult, von Willebrand Factor/metabolism
Pubmed
Web of science
Create date
01/02/2018 20:24
Last modification date
17/09/2020 8:14
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