Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know
Details
Serval ID
serval:BIB_1E3BBD9FBBB8
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know
Journal
Nature Medicine
ISSN
1078-8956 (Print)
Publication state
Published
Issued date
08/2004
Volume
10
Number
8
Pages
806-10
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Aug
Research Support, Non-U.S. Gov't
Review --- Old month value: Aug
Abstract
The field of vaccinology began in ignorance of how protection was instilled in vaccine recipients. Today, a greater knowledge of immunology allows us to better understand what is being stimulated by various vaccines that leads to their protective effects: that is, their correlates of protection. Here we describe what is known about the correlates of protection for existing vaccines against a range of different viral diseases and discuss the correlates of protection against disease during natural infection with HIV-1. We will also discuss why it is important to design phase 3 clinical trials of HIV vaccines to determine the correlates of protection for each individual vaccine.
Keywords
AIDS Vaccines/*immunology
Antibody Formation/immunology
HIV Infections/*immunology
*Hiv-1
Humans
Immunity, Cellular/immunology
Monitoring, Immunologic/methods
Virus Diseases/*immunology
Pubmed
Web of science
Create date
25/01/2008 16:14
Last modification date
20/08/2019 13:54