Diversion of peripheral thyroxine metabolism from activating to inactivating pathways during complete fasting
Details
Serval ID
serval:BIB_1E21CA7E03D9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diversion of peripheral thyroxine metabolism from activating to inactivating pathways during complete fasting
Journal
Journal of Clinical Endocrinology and Metabolism
ISSN
0021-972X (Print)
Publication state
Published
Issued date
07/1975
Volume
41
Number
1
Pages
191-4
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jul
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jul
Abstract
In 9 euthyroid obese volunteers, as previously reported, 4 weeks of total caloric deprivation resulted in a striking decrease in serum 3,5;3'-triiodothyronine (T3) concentration. The present studies reveal that this decrease in serum T3 is accompanied by a proportionately similar increase in the serum concentration of 3,3',5' -T3 (reverse T3; rT3). In four additional obese volunteers given suppressive doses of sodium-Lthyroxine (T4) for 1 month prior to fasting, serum T3 concentration declined sharply during a 6-11 day period of fast, while rT3 concentration increased strikingly. Concentrations of both T3 and rT3 returned to control values during a 5 day period of refeeding. The findings indicate that caloric deprivation results in an alteration in peripheral T4 metabolism away from generation of T3 and toward the generation of rT3. Since the former is more active than T4, and the latter is essentially inactive, caloric deprivation appears to shunt peripheral T4 metabolism from activating to inactivating pathways.
Keywords
Adult
Diet
*Fasting
Female
Humans
Male
Middle Aged
Obesity/blood
Radioimmunoassay
Thyroxine/*blood/pharmacology
Triiodothyronine/blood
Pubmed
Web of science
Create date
25/01/2008 15:00
Last modification date
20/08/2019 13:54