Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis.

Details

Serval ID
serval:BIB_1D9EF11DA192
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis.
Journal
Biomed Research International
Author(s)
Bonnier G., Roche A., Romascano D., Simioni S., Meskaldji D.E., Rotzinger D., Lin Y.C., Menegaz G., Schluep M., Du Pasquier R., Sumpf T.J., Frahm J., Thiran J.P., Krueger G., Granziera C.
ISSN
2314-6141 (Electronic)
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
2015
Pages
569123
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
INTRODUCTION: Local microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based lesion pathology in cognition and disability.
METHODS: 36 relapsing-remitting MS subjects and 18 healthy controls underwent neurological, cognitive, behavioural examinations and 3 T MRI including (i) fluid attenuated inversion recovery, double inversion recovery, and magnetization-prepared gradient echo for lesion count; (ii) T1, T2, and T2(*) relaxometry and magnetisation transfer imaging for lesion tissue characterization. Lesions were classified according to the extent of inflammation/neurodegeneration. A generalized linear model assessed the contribution of lesion groups to clinical performances.
RESULTS: Four lesion groups were identified and characterized by (1) absence of significant alterations, (2) prevalent inflammation, (3) concomitant inflammation and microdegeneration, and (4) prevalent tissue loss. Groups 1, 3, 4 correlated with general disability (Adj-R (2) = 0.6; P = 0.0005), executive function (Adj-R (2) = 0.5; P = 0.004), verbal memory (Adj-R (2) = 0.4; P = 0.02), and attention (Adj-R (2) = 0.5; P = 0.002).
CONCLUSION: Multicontrast MRI provides a new approach to infer in vivo histopathology of plaques. Our results support evidence that neurodegeneration is the major determinant of patients' disability and cognitive dysfunction.
Keywords
Adult, Cerebellum/pathology, Contrast Media, Female, Humans, Inflammation/complications, Inflammation/pathology, Linear Models, Magnetic Resonance Imaging, Male, Multiple Sclerosis/complications, Multiple Sclerosis/diagnosis, Multiple Sclerosis, Relapsing-Remitting/complications, Multiple Sclerosis, Relapsing-Remitting/diagnosis, Multivariate Analysis, Nerve Degeneration/complications, Nerve Degeneration/diagnosis
Pubmed
Web of science
Open Access
Yes
Create date
28/08/2015 18:48
Last modification date
20/08/2019 13:53
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