Association between circulating cytokine levels, diabetes and insulin resistance in a population-based sample (CoLaus study).

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State: Public
Version: author
Serval ID
serval:BIB_1D6DF8C43686
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association between circulating cytokine levels, diabetes and insulin resistance in a population-based sample (CoLaus study).
Journal
Clinical Endocrinology
Author(s)
Marques-Vidal P., Bastardot F., von Känel R., Paccaud F., Preisig M., Waeber G., Vollenweider P.
ISSN
1365-2265 (Electronic)
ISSN-L
0300-0664
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
78
Number
2
Pages
232-241
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
OBJECTIVE: The associations between inflammation, diabetes and insulin resistance remain controversial. Hence, we assessed the associations between diabetes, insulin resistance (using HOMA-IR) and metabolic syndrome with the inflammatory markers high-sensitive C-reactive protein (hs-CRP), interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α).
DESIGN: Cross-sectional study.
PARTICIPANTS: Two thousand eight hundred and eighty-four men and 3201 women, aged 35-75, participated in this study.
METHODS: C-reactive protein was assessed by immunoassay and cytokines by multiplexed flow cytometric assay. In a subgroup of 532 participants, an oral glucose tolerance test (OGTT) was performed to screen for impaired glucose tolerance (IGT).
RESULTS: IL-6, TNF-α and hs-CRP were significantly and positively correlated with fasting plasma glucose (FPG), insulin and HOMA-IR. Participants with diabetes had higher IL-6, TNF-α and hs-CRP levels than participants without diabetes; this difference persisted for hs-CRP after multivariate adjustment. Participants with metabolic syndrome had increased IL-6, TNF-α and hs-CRP levels; these differences persisted after multivariate adjustment. Participants in the highest quartile of HOMA-IR had increased IL-6, TNF-α and hs-CRP levels; these differences persisted for TNF-α and hs-CRP after multivariate adjustment. No association was found between IL-1β levels and all diabetes and insulin resistance markers studied. Finally, participants with IGT had higher hs-CRP levels than participants with a normal OGTT, but this difference disappeared after controlling for body mass index (BMI).
CONCLUSION: We found that subjects with diabetes, metabolic syndrome and increased insulin resistance had increased levels of IL6, TNF-α and hs-CRP, while no association was found with IL-1β. The increased inflammatory state of subjects with IGT is partially explained by increased BMI.
Keywords
Colaus Study
Pubmed
Web of science
Create date
02/05/2012 15:28
Last modification date
30/05/2020 7:08
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