Role of trabecular microarchitecture and its heterogeneity parameters in the mechanical behavior of ex vivo human L3 vertebrae.

Details

Serval ID
serval:BIB_1D52A934A6E1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Role of trabecular microarchitecture and its heterogeneity parameters in the mechanical behavior of ex vivo human L3 vertebrae.
Journal
Journal of Bone and Mineral Research
Author(s)
Wegrzyn J., Roux J.P., Arlot M.E., Boutroy S., Vilayphiou N., Guyen O., Delmas P.D., Chapurlat R., Bouxsein M.L.
ISSN
1523-4681 (Electronic)
ISSN-L
0884-0431
Publication state
Published
Issued date
2010
Volume
25
Number
11
Pages
2324-2331
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Low bone mineral density (BMD) is a strong risk factor for vertebral fracture risk in osteoporosis. However, many fractures occur in people with moderately decreased or normal BMD. Our aim was to assess the contributions of trabecular microarchitecture and its heterogeneity to the mechanical behavior of human lumbar vertebrae. Twenty-one human L(3) vertebrae were analyzed for BMD by dual-energy X-ray absorptiometry (DXA) and microarchitecture by high-resolution peripheral quantitative computed tomography (HR-pQCT) and then tested in axial compression. Microarchitecture heterogeneity was assessed using two vertically oriented virtual biopsies--one anterior (Ant) and one posterior (Post)--each divided into three zones (superior, middle, and inferior) and using the whole vertebral trabecular volume for the intraindividual distribution of trabecular separation (Tb.Sp*SD). Heterogeneity parameters were defined as (1) ratios of anterior to posterior microarchitectural parameters and (2) the coefficient of variation of microarchitectural parameters from the superior, middle, and inferior zones. BMD alone explained up to 44% of the variability in vertebral mechanical behavior, bone volume fraction (BV/TV) up to 53%, and trabecular architecture up to 66%. Importantly, bone mass (BMD or BV/TV) in combination with microarchitecture and its heterogeneity improved the prediction of vertebral mechanical behavior, together explaining up to 86% of the variability in vertebral failure load. In conclusion, our data indicate that regional variation of microarchitecture assessment expressed by heterogeneity parameters may enhance prediction of vertebral fracture risk.
Keywords
Aged, Aged, 80 and over, Biomechanical Phenomena/physiology, Female, Humans, Lumbar Vertebrae/anatomy & histology, Lumbar Vertebrae/physiology, Male, Middle Aged, Models, Biological, Organ Size, Regression Analysis, Tomography, X-Ray Computed
Pubmed
Web of science
Create date
26/08/2014 18:50
Last modification date
17/01/2020 7:59
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