Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension.

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State: Public
Version: author
Serval ID
serval:BIB_1D2BE11940C7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension.
Journal
Human Molecular Genetics
Author(s)
Guessous I., Dobrinas M., Kutalik Z., Pruijm M., Ehret G., Maillard M., Bergmann S., Beckmann J.S., Cusi D., Rizzi F., Cappuccio F., Cornuz J., Paccaud F., Mooser V., Gaspoz J.M., Waeber G., Burnier M., Vollenweider P., Eap C.B., Bochud M.
ISSN
1460-2083 (Electronic)
ISSN-L
0964-6906
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
21
Number
14
Pages
3283-3292
Language
english
Notes
Publication types: JOURNAL ARTICLE
Abstract
The 15q24.1 locus, including CYP1A2, is associated with blood pressure (BP). The CYP1A2 rs762551 C allele is associated with lower CYP1A2 enzyme activity. CYP1A2 metabolizes caffeine and is induced by smoking. The association of caffeine consumption with hypertension remains controversial. We explored the effects of CYP1A2 variants and CYP1A2 enzyme activity on BP, focusing on caffeine as the potential mediator of CYP1A2 effects. Four observational (n = 16 719) and one quasi-experimental studies (n = 106) including European adults were conducted. Outcome measures were BP, caffeine intake, CYP1A2 activity and polymorphisms rs762551, rs1133323 and rs1378942. CYP1A2 variants were associated with hypertension in non-smokers, but not in smokers (CYP1A2-smoking interaction P = 0.01). Odds ratios (95% CIs) for hypertension for rs762551 CC, CA and AA genotypes were 1 (reference), 0.78 (0.59-1.02) and 0.66 (0.50-0.86), respectively, P = 0.004. Results were similar for the other variants. Higher CYP1A2 activity was linearly associated with lower BP after quitting smoking (P = 0.049 and P = 0.02 for systolic and diastolic BP, respectively), but not while smoking. In non-smokers, the CYP1A2 variants were associated with higher reported caffeine intake, which in turn was associated with lower odds of hypertension and lower BP (P = 0.01). In Mendelian randomization analyses using rs1133323 as instrument, each cup of caffeinated beverage was negatively associated with systolic BP [-9.57 (-16.22, -2.91) mmHg]. The associations of CYP1A2 variants with BP were modified by reported caffeine intake. These observational and quasi-experimental results strongly support a causal role of CYP1A2 in BP control via caffeine intake.
Pubmed
Web of science
Open Access
Yes
Create date
02/05/2012 15:32
Last modification date
28/05/2020 7:08
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