Convergent evolution of venom gland transcriptomes across Metazoa.

Details

Ressource 1Download: Zancolli_et_al_Convergence_venom_transcriptomes_Biorxiv.pdf (2009.76 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Secondary document(s)
Download: 2022_PNAS_Zancolli et al_Convergent evolution of venom gland transcriptomes.pdf (1839.79 [Ko])
State: Public
Version: Supplementary document
License: Not specified
Serval ID
serval:BIB_1D15F06B4071
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Convergent evolution of venom gland transcriptomes across Metazoa.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Zancolli G., Reijnders M., Waterhouse R.M., Robinson-Rechavi M.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Publication state
Published
Issued date
04/01/2022
Peer-reviewed
Oui
Volume
119
Number
1
Pages
e2111392119
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Animals have repeatedly evolved specialized organs and anatomical structures to produce and deliver a mixture of potent bioactive molecules to subdue prey or predators-venom. This makes it one of the most widespread, convergent functions in the animal kingdom. Whether animals have adopted the same genetic toolkit to evolved venom systems is a fascinating question that still eludes us. Here, we performed a comparative analysis of venom gland transcriptomes from 20 venomous species spanning the main Metazoan lineages to test whether different animals have independently adopted similar molecular mechanisms to perform the same function. We found a strong convergence in gene expression profiles, with venom glands being more similar to each other than to any other tissue from the same species, and their differences closely mirroring the species phylogeny. Although venom glands secrete some of the fastest evolving molecules (toxins), their gene expression does not evolve faster than evolutionarily older tissues. We found 15 venom gland-specific gene modules enriched in endoplasmic reticulum stress and unfolded protein response pathways, indicating that animals have independently adopted stress response mechanisms to cope with mass production of toxins. This, in turn, activates regulatory networks for epithelial development, cell turnover, and maintenance, which seem composed of both convergent and lineage-specific factors, possibly reflecting the different developmental origins of venom glands. This study represents a first step toward an understanding of the molecular mechanisms underlying the repeated evolution of one of the most successful adaptive traits in the animal kingdom.
Keywords
convergent evolution, evolutionary novelties, gene expression, stress response, venom
Pubmed
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Careers / PP00P3_170664
European Commission / H2020 / 845674
Create date
13/07/2021 10:43
Last modification date
21/11/2022 8:29
Usage data