18F-choline and/or 11C-acetate positron emission tomography: detection of residual or progressive subclinical disease at very low prostate-specific antigen values (<1 ng/mL) after radical prostatectomy

Details

Serval ID
serval:BIB_1D003045295E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
18F-choline and/or 11C-acetate positron emission tomography: detection of residual or progressive subclinical disease at very low prostate-specific antigen values (<1 ng/mL) after radical prostatectomy
Journal
BJU International
Author(s)
Vees  H., Buchegger  F., Albrecht  S., Khan  H., Husarik  D., Zaidi  H., Soloviev  D., Hany  T. F., Miralbell  R.
ISSN
1464-4096 (Print)
Publication state
Published
Issued date
06/2007
Volume
99
Number
6
Pages
1415-20
Notes
Evaluation Studies
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't --- Old month value: Jun
Abstract
OBJECTIVES: To assess the value of positron emission tomography (PET)/computed tomography (CT) with either (18)F-choline and/or (11)C-acetate, of residual or recurrent tumour after radical prostatectomy (RP) in patients with a prostate-specific antigen (PSA) level of <1 ng/mL and referred for adjuvant or salvage radiotherapy. PATIENTS AND METHODS: In all, 22 PET/CT studies were performed, 11 with (18)F-choline (group A) and 11 with (11)C-acetate (group B), in 20 consecutive patients (two undergoing PET/CT scans with both tracers). The median (range) PSA level before PET/CT was 0.33 (0.08-0.76) ng/mL. Endorectal-coil magnetic resonance imaging (MRI) was used in 18 patients. Nineteen patients were eligible for evaluation of biochemical response after salvage radiotherapy. RESULTS: There was abnormal local tracer uptake in five and six patients in group A and B, respectively. Except for a single positive obturator lymph node, there was no other site of metastasis. In the two patients evaluated with both tracers there was no pathological uptake. Endorectal MRI was locally positive in 15 of 18 patients; 12 of 19 responded with a marked decrease in PSA level (half or more from baseline) 6 months after salvage radiotherapy. CONCLUSIONS: Although (18)F-choline and (11)C-acetate PET/CT studies succeeded in detecting local residual or recurrent disease in about half the patients with PSA levels of <1 ng/mL after RP, these studies cannot yet be recommended as a standard diagnostic tool for early relapse or suspicion of subclinical minimally persistent disease after surgery. Endorectal MRI might be more helpful, especially in patients with a low likelihood of distant metastases. Nevertheless, further research with (18)F-choline and/or (11)C-acetate PET with optimal spatial resolution might be needed for patients with a high risk of distant relapse after RP even at low PSA values.
Keywords
Acetates/diagnostic use Aged Carbon Radioisotopes/diagnostic use Choline/diagnostic use Fluorine Radioisotopes/diagnostic use Fluorodeoxyglucose F18/diagnostic use Humans Magnetic Resonance Imaging Male Middle Aged Neoplasm Recurrence, Local/*radiography/*radionuclide imaging/radiotherapy Neoplasm, Residual/radiography/radionuclide imaging/radiotherapy/surgery Positron-Emission Tomography/*methods Prostate-Specific Antigen/blood Prostatectomy/methods Prostatic Neoplasms/*radiography/*radionuclide imaging/radiotherapy/surgery Radiopharmaceuticals/diagnostic use Salvage Therapy/methods Tomography, X-Ray Computed/*methods Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 11:27
Last modification date
20/08/2019 12:53
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