Phage Therapy: A New Horizon in the Antibacterial Treatment of Oral Pathogens.

Details

Serval ID
serval:BIB_1CA77066BF74
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Phage Therapy: A New Horizon in the Antibacterial Treatment of Oral Pathogens.
Journal
Current topics in medicinal chemistry
Author(s)
Shlezinger M., Khalifa L., Houri-Haddad Y., Coppenhagen-Glazer S., Resch G., Que Y.A., Beyth S., Dorfman E., Hazan R., Beyth N.
ISSN
1873-4294 (Electronic)
ISSN-L
1568-0266
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
17
Number
10
Pages
1199-1211
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Dental diseases are perhaps the most prevalent infection-related diseases in humans. Biofilm is involved in almost every infectious disease compromising oral health, notably caries, periodontal disease, gingivitis, endodontic infections and peri-implantitis. Current therapies of biofilm-derived oral infections lack sensitivity; they are not species-specific and kill pathogenic species as well as commensal species, which are protective against the formation of pathogenic biofilms. Moreover, antibiotics have a limited effect on biofilm and are almost unused in oral diseases. A promising alternative approach is bacteriophage (phage) therapy. Phages play a key role in the natural balance in a predator-prey relationship with bacteria and thus have the potential to be efficient anti-bacterial agents. Phages are highly efficient against biofilm, strain specific and easy to isolate and manipulate. Thus, like in many other medicinal fields, phage therapy offers new horizons to dentistry, both therapeutics and research. The present review presents the etiology of common oral diseases, characterization of the infection and the treatment challenges of phage therapy in dentistry. Recent findings and development in the use of phages for prevention, control, and treatment of oral infections as well as possibilities of engineering the oral microbiome are discussed.

Keywords
Animals, Bacteria/virology, Bacteriophages/pathogenicity, Biofilms/growth & development, Humans, Mouth Diseases/microbiology, Mouth Diseases/prevention & control, Mouth Diseases/therapy, Phage Therapy/methods, Phage Therapy/trends
Pubmed
Create date
03/04/2017 14:22
Last modification date
20/08/2019 13:53
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